Tephly T R, Wagner G, Sedman R, Piper W
Fed Proc. 1978 Jan;37(1):35-9.
Studying the mechanism of interaction of metals with enzymes of the heme biosynthetic pathway has revealed a great deal of understanding of the regulation of the pathway and a possible insight into the toxicology of certain metals. Both positive and negative effects of metals on heme biosynthesis and catabolism can be demonstrated. The understanding of these interactions has given us a clearer picture of certain of the descriptive events known to occur in toxic states induced by these metals. Unfortunately, the studies have also driven us to appreciate the even more complex nature of the biosynthetic and metabolic pathways for heme than was originally hypothesized. It can be predicted that the next 5 years should lead to many more revelations and potential treatment modalities for toxic states induced by metals or genetic diseases where heme biosynthesis does not occur normally.
对金属与血红素生物合成途径中酶的相互作用机制进行研究，使我们对该途径的调节有了深入了解，并对某些金属的毒理学有了可能的认识。金属对血红素生物合成和分解代谢的正负效应都可以得到证实。对这些相互作用的理解，让我们更清楚地了解了在这些金属诱导的毒性状态下已知发生的某些描述性事件。不幸的是，这些研究也让我们认识到，血红素的生物合成和代谢途径比最初设想的更加复杂。可以预测，在未来5年里，对于由金属或血红素生物合成不正常的遗传疾病所导致的毒性状态，将会有更多的新发现和潜在的治疗方法。
