Department of Internal Medicine, Yale Medical School, 333 Cedar St, New Haven, CT, 06510, USA.
Lurie Center for Autism, 1 Maguire Road, Lexington, MA, 02421, USA.
J Autism Dev Disord. 2022 Feb;52(2):852-862. doi: 10.1007/s10803-021-04979-w. Epub 2021 Apr 10.
The purpose of the study was to characterize repetitive phenomena in Williams syndrome (WS). The parents of 60 subjects with WS completed the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) or Children's Y-BOCS, the Yale Global Tic Severity Scale, the Stereotyped Behavior Scale, and the Spence Children's Anxiety Scale-Parent Version. Nineteen males and 41 females participated in the study. Six subjects (10%) had obsessions only, six (10%) had compulsions only, and eleven (18%) had at least one obsession and at least one compulsion. None of the subjects had tics. Fifty subjects (83.3%) endorsed at least one stereotypy. Increased anxiety was associated with increased severity of obsessions, but not severity of compulsions or stereotypies.
本研究旨在描述威廉姆斯综合征（WS）中的重复现象。60 名 WS 患者的父母完成了耶鲁-布朗强迫量表（Y-BOCS）或儿童耶鲁-布朗强迫量表、耶鲁全球抽动严重程度量表、刻板行为量表和斯宾塞儿童焦虑量表-父母版。19 名男性和 41 名女性参与了研究。6 名患者（10%）仅有强迫观念，6 名（10%）仅有强迫行为，11 名（18%）至少有一个强迫观念和至少一个强迫行为。没有患者出现抽动。50 名患者（83.3%）至少有一个刻板行为。焦虑增加与强迫观念严重程度增加相关，但与强迫行为或刻板行为严重程度无关。
