Ayee Manuela A A, Bunker Brendan C, De Groot Jordan L
Department of Engineering, Dordt University, Sioux Center, IA, United States.
Department of Engineering, Dordt University, Sioux Center, IA, United States.
Curr Top Membr. 2020;86:57-81. doi: 10.1016/bs.ctm.2020.08.001. Epub 2020 Sep 14.
Bioactive omega-3 polyunsaturated fatty acids have been shown to reduce the risk of death in patients with cardiovascular disease and alleviate the symptoms of other inflammatory diseases. However, the mechanisms of action of these effects remain unclear. It has been postulated that omega-3 polyunsaturated fatty acids modify cell membranes by incorporation into the membrane and altering the signaling properties of cellular receptors. In this chapter, we explore the effects of omega-3 polyunsaturated fatty acids on cell membrane structure and function. We present a review of the current evidence for the health benefits of these compounds and explore the molecular mechanisms through which omega-3 polyunsaturated fatty acids interact with membrane lipids and modulate bilayer structure. Using computational models of multicomponent phospholipid bilayers, we assess the consequences of incorporation of these fatty acids on membrane lipid packing, water permeation, and membrane structure.
生物活性ω-3多不饱和脂肪酸已被证明可降低心血管疾病患者的死亡风险，并减轻其他炎症性疾病的症状。然而，这些作用的作用机制仍不清楚。据推测，ω-3多不饱和脂肪酸通过掺入细胞膜并改变细胞受体的信号特性来修饰细胞膜。在本章中，我们探讨了ω-3多不饱和脂肪酸对细胞膜结构和功能的影响。我们综述了这些化合物对健康有益的当前证据，并探讨了ω-3多不饱和脂肪酸与膜脂相互作用并调节双层结构的分子机制。使用多组分磷脂双层的计算模型，我们评估了这些脂肪酸掺入对膜脂堆积、水渗透和膜结构的影响。
