Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Internal Medicine, Affiliated Hospital of Qingdao University, Qingdao, China.
Neurosci Lett. 2021 May 29;754:135879. doi: 10.1016/j.neulet.2021.135879. Epub 2021 Apr 7.
We aimed to estimate the role of vacuolar protein sorting 13C (VPS13C) gene single nucleotide polymorphism (SNP) rs2414739 variant in the risk of PD by meta-analysis.
Five eligible case-control studies including 2796 PD cases and 4138 health controls involved in this meta-analysis. The fixed or random effect model was selected based on the heterogeneity of the included studies which detected by I and Q tests. The association between rs2414739 polymorphism and the risk of PD was evaluated using the pooled odds ratios (OR) and 95 % confidence interval (95 %CI). Sensitivity analysis was used to test the stability of the results. Funnel plot and Begg's test were employed to verified publication bias.
The results of our meta-analysis showed a significant correlation between VPS13C rs2424739 gene polymorphism and PD susceptibility in Allele model (A versus vs. G: OR = 1.14, 95 %CI = 1.05-1.23, p = 0.002), dominant model (GG + AG vs. AA: OR = 0.86, 95 %CI = 0.78-0.95, p = 0.004), heterozygote model (AG vs. AA: OR = 0.87, 95 %CI = 0.77-0.99, p = 0.04), homozygote model (GG vs. AA: OR = 0.76, 95 %CI = 0.60-0.96, p = 0.02). Surprisingly, we did not find a significant statistical difference between VPS13C rs2414739 polymorphism and PD risk in Chinese cohort in the regional stratified analysis.
This meta-analysis suggests that VPS13C rs2414739 polymorphism might act as a genetic predisposition factor for PD, whereas does not include Chinese population.
通过荟萃分析，评估液泡分选蛋白 13C（VPS13C）基因单核苷酸多态性（SNP）rs2414739 变体在帕金森病（PD）风险中的作用。
本荟萃分析纳入了五项符合条件的病例对照研究，共包括 2796 例 PD 病例和 4138 例健康对照。采用 I ² 和 Q 检验来检测纳入研究的异质性，并选择固定效应或随机效应模型。使用合并优势比（OR）和 95%置信区间（95%CI）来评估 rs2414739 多态性与 PD 风险之间的关联。敏感性分析用于检验结果的稳定性。漏斗图和 Begg 检验用于验证发表偏倚。
荟萃分析结果显示，VPS13C rs2424739 基因多态性与 PD 易感性在等位基因模型（A 对 G：OR=1.14，95%CI=1.05-1.23，p=0.002）、显性模型（GG+AG 对 AA：OR=0.86，95%CI=0.78-0.95，p=0.004）、杂合子模型（AG 对 AA：OR=0.87，95%CI=0.77-0.99，p=0.04）和纯合子模型（GG 对 AA：OR=0.76，95%CI=0.60-0.96，p=0.02）中存在显著相关性。令人惊讶的是，我们在亚组分析中未发现 VPS13C rs2414739 多态性与中国人群 PD 风险之间存在显著的统计学差异。
本荟萃分析表明，VPS13C rs2414739 多态性可能是 PD 的遗传易感性因素之一，但不包括中国人群。
