González Lorena, Díaz María E, Miquet Johanna G, Sotelo Ana I, Dominici Fernando P
Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina.
Universidad Nacional de Luján, CONICET, Instituto de Ecología y Desarrollo Sustentable (INEDES), Buenos Aires, Argentina.
Trends Endocrinol Metab. 2021 Jun;32(6):403-414. doi: 10.1016/j.tem.2021.03.004. Epub 2021 Apr 7.
Epidermal growth factor receptor (EGFR) signaling has a central role in the regenerative response of the liver upon injury and is involved in cellular transformation linked to chronic damage. Hepatic EGFR expression, trafficking, and signaling are regulated by growth hormone (GH). Chronically elevated GH levels are associated with liver cancer development and progression in mice. Studies in different in vivo experimental models indicate that EGF and GH mutually crossregulate in a complex manner. Several factors, such as the extent of exposure to supraphysiological GH levels and the pattern of GH administration, are important variables to be considered in exploring the interplay between the two hormones in connection with the progression of hepatic tumors.
表皮生长因子受体（EGFR）信号传导在肝脏损伤后的再生反应中起核心作用，并参与与慢性损伤相关的细胞转化。肝脏EGFR的表达、运输和信号传导受生长激素（GH）调节。在小鼠中，慢性升高的GH水平与肝癌的发生和进展有关。不同体内实验模型的研究表明，表皮生长因子（EGF）和GH以复杂的方式相互交叉调节。在探索这两种激素与肝肿瘤进展之间的相互作用时，几个因素，如超生理GH水平的暴露程度和GH给药模式，是需要考虑的重要变量。
