Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
Transfus Apher Sci. 2021 Jun;60(3):103124. doi: 10.1016/j.transci.2021.103124. Epub 2021 Apr 2.
Rhesus (Rh) blood group system is clinically the most significant protein-based grouping system. The Rh system is of vital importance in blood transfusion, and incompatibility between the donor and recipient leads to alloimmunization. Alloimmunization is commonly seen in multiple-transfusion recipients (e.g. thalassemia patients). There are a few studies about the prevalence of Rh antigens, except for D, in Iran; and regarding the high prevalence of thalassemia in the country, in this study we have determined antigens and phenotypes of the Rh among population of regular blood donors with the aim of developing a detailed Rh databank.
This cross-sectional study randomly enrolled 3000 regular blood donors from three provinces of Sistan-Balouchestan, Khuzestan and Gilan in Iran, from September 2018 to May 2019. A fully automated system, based on hemagglutination, was used to Rh typing of blood samples.
The prevalence of Rh antigens were as follows: D: 88.9 %; E: 30.9 %; C: 74.1 %; e: 96.2 %; and c: 72.8 %. The most common antigen and phenotype were "e" and Rr (DCcee), respectively.
Due to the high rate of alloimmunization incidence against Rh blood group antigens among multiple transfusion recipients, development of regular blood donor's Rh databank can facilitate extensive matching for the Rh antigens and it likely reduces the risk of alloimmunization.
恒河猴（Rh）血型系统是临床上最重要的基于蛋白质的分组系统。Rh 系统在输血中至关重要，供体和受体之间的不相容性会导致同种免疫。同种免疫在多次输血的受者中很常见（例如地中海贫血患者）。伊朗有一些关于 Rh 抗原（除 D 抗原外）流行率的研究；鉴于该国地中海贫血的高发率，在这项研究中，我们确定了定期献血者人群中 Rh 抗原和表型，旨在建立一个详细的 Rh 数据库。
本横断面研究于 2018 年 9 月至 2019 年 5 月期间，在伊朗锡斯坦-俾路支省、胡齐斯坦省和吉兰省随机招募了 3000 名定期献血者。采用基于血凝的全自动系统对血液样本进行 Rh 定型。
Rh 抗原的流行率如下：D：88.9%；E：30.9%；C：74.1%；e：96.2%；和 c：72.8%。最常见的抗原和表型分别为“e”和 Rr（DCcee）。
由于多次输血受者对 Rh 血型抗原发生同种免疫的发生率较高，建立定期献血者的 Rh 数据库可以方便广泛匹配 Rh 抗原，从而降低同种免疫的风险。
