Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, School of Psychology, Center for Studies of Psychological Application, Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, China.
Plateau Brain Science Research Center, South China Normal University/Tibet University, China.
Int J Psychophysiol. 2021 Jul;165:18-28. doi: 10.1016/j.ijpsycho.2021.03.012. Epub 2021 Apr 8.
High-altitude exposure induces the decline of spatial manipulation such as mental rotation which is limited by working memory capacity, but the underlying neuropsychological effect remains to be identified. We evaluated the mental rotation task and the contralateral delay activity (CDA) task under hypoxia environment using the event-related potential. When compared with the controls, the behavior response was slowed on two tasks in the high-altitude group. The declined mental rotation and the decreased working memory capacity were synchronously related to the amplitudes of P50 and CDA, respectively. The P50 during mental rotation was positively correlated to that of rotation-related negativity (RRN) component, so was with the CDA. Time-frequency analysis showed that the beta/alpha power in mental rotation and the theta/alpha/beta power in CDA were enhanced in the high-altitude group. The present study might suggest that the decline of working memory capacity induced poor performance of mental rotation, which may be derived from a bottom-up sensory gating deficit reflected by P50.
高原暴露会导致空间操作能力下降，例如心理旋转，而心理旋转受到工作记忆容量的限制，但潜在的神经心理学效应仍有待确定。我们使用事件相关电位评估了在低氧环境下的心理旋转任务和对侧延迟活动（CDA）任务。与对照组相比，高原组在两项任务中的行为反应均减慢。心理旋转能力下降和工作记忆容量降低分别与 P50 和 CDA 的幅度同步相关。心理旋转时的 P50 与旋转相关负波（RRN）成分的 P50 呈正相关，与 CDA 的 P50 也呈正相关。时频分析显示，高原组的心理旋转的β/α功率和 CDA 的θ/α/β功率增强。本研究可能表明，工作记忆容量下降导致心理旋转表现不佳，这可能源于 P50 反映的自下而上的感觉门控缺陷。
