Department of Biosystems and Agriculture Engineering, Michigan State University, East Lansing, MI, United States; Global Alliance for Rapid Diagnostics, Michigan State University, East Lansing, MI, United States.
Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, United States.
Int J Pharm. 2021 Jun 1;602:120580. doi: 10.1016/j.ijpharm.2021.120580. Epub 2021 Apr 9.
Counterfeiting has never been more challenging than during the COVID-19 pandemic as counterfeit test kits and therapeutics have been discovered in the market. Current anti-counterfeiting labels have weaknesses: they can either be duplicated easily, are expensive or ill-suited for the existing complex supply chains. While RFID tags provide for an excellent alternative to current anti-counterfeiting methods, they can prove to be expensive and other routes involving nanomaterials can be difficult to encrypt. A DNA based anticounterfeiting system has significant advantages such as relative ease of synthesis and vast data storage abilities, along with great potential in encryption. Although DNA is equipped with such beneficial properties, major challenges that limit its real-world anti-counterfeiting applications include protection in harsh environments, rapid inexpensive sequence determination, and its attachment to products. This review elaborates the current progress of DNA based anti-counterfeiting systems and identifies technological gaps that need to be filled for its practical application. Progress made on addressing the primary challenges associated with the use of DNA, and potential solutions are discussed.
在 COVID-19 大流行期间，伪造行为从未如此具有挑战性，因为市场上已经发现了假冒的检测试剂盒和治疗方法。当前的防伪标签存在弱点：它们要么容易被复制，要么成本高昂，要么不适合现有的复杂供应链。虽然 RFID 标签为当前的防伪方法提供了极好的替代品，但它们可能证明成本高昂，而涉及纳米材料的其他途径可能难以加密。基于 DNA 的防伪系统具有相对容易合成和大容量数据存储能力等显著优势，并且在加密方面具有很大的潜力。尽管 DNA 具有这些有益的特性，但限制其在防伪实际应用中的主要挑战包括在恶劣环境中的保护、快速廉价的序列确定以及与产品的连接。本综述详细阐述了基于 DNA 的防伪系统的当前进展，并确定了其实际应用需要填补的技术空白。讨论了在解决与使用 DNA 相关的主要挑战方面取得的进展以及潜在的解决方案。
