Student Research Committee, Department of Environmental Health Engineering, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Biostatistics and Epidemiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
J Trace Elem Med Biol. 2021 Jul;66:126757. doi: 10.1016/j.jtemb.2021.126757. Epub 2021 Apr 5.
The incidence of Metabolic Syndrome (MetS) has been growing rapidly and is rising to pandemic proportions. Although obesity is a primary risk factor for the enhancement of these conditions, not all obese individuals develop metabolic syndrome, indicating that the risk for developing MetS is impacted by other genetic and/or environmental factors such as heavy metals. Therefore, the present study focused on the association between exposures to heavy metal and MetS.
Urine samples were collected from 150 participants (75 patients with MetS and 75 healthy participants), which were used from Hoveyzeh Cohort center. To make a quantitative comparison between the two groups, Man-Whitney nonparametric test was used. The logistic regression was performed adjusted for age, demographic, lifestyle factor, physical activity, occupational history and urine creatinine.
The results of logistic regression showed that OR and 95 % CI for Cd, Pb, Sr, As and Fe concentration were still significant after adjusting for urine creatinine. Moreover, there was a relationship between Cd and Pb levels and waist circumstance (WC). After adjusting for urine creatinine, age, sex, occupation, smoking status, education and place of residence, only Pb concentration was showed a significant association with systolic blood pressure (SBP). The subjects with high urine level of Cd had the high odds (OR: 6.273; 95 % Cl: 1.783-22.070) of MetS and low high-density lipoprotein (HDL-C). The relationship between As concentration and high fasting blood sugars confirmed the previous evidence suggesting that high As level can cause diabetes.
These results indicated that outbreak of MetS and its component are associated with heavy metal concentrations in urine.
代谢综合征（MetS）的发病率迅速增长，呈流行趋势。虽然肥胖是这些疾病加重的主要危险因素，但并非所有肥胖者都会发生代谢综合征，这表明发生代谢综合征的风险受到其他遗传和/或环境因素的影响，如重金属。因此，本研究集中探讨了重金属暴露与代谢综合征之间的关系。
从 Hoveyzeh 队列中心采集了 150 名参与者（75 名代谢综合征患者和 75 名健康参与者）的尿液样本。为了在两组之间进行定量比较，使用了 Man-Whitney 非参数检验。对年龄、人口统计学、生活方式因素、体力活动、职业史和尿肌酐进行了调整，然后进行了逻辑回归分析。
逻辑回归的结果表明，在校正尿肌酐后，Cd、Pb、Sr、As 和 Fe 浓度的 OR 和 95%CI 仍然显著。此外，Cd 和 Pb 水平与腰围（WC）之间存在关系。在校正尿肌酐、年龄、性别、职业、吸烟状况、教育和居住地后，只有 Pb 浓度与收缩压（SBP）呈显著相关。尿液中 Cd 含量高的受试者发生代谢综合征的几率较高（OR：6.273；95%Cl：1.783-22.070），高密度脂蛋白（HDL-C）水平较低。As 浓度与空腹血糖高之间的关系证实了先前的证据，即高 As 水平可导致糖尿病。
这些结果表明，代谢综合征及其成分的爆发与尿液中重金属浓度有关。
