Beex L V, Mackenzie M A, Raemaekers J M, Smals A G, Benraad T J, Kloppenborg P W
Department of Medicine, University of Nijmegen, The Netherlands.
Eur J Cancer Clin Oncol. 1988 Apr;24(4):719-21. doi: 10.1016/0277-5379(88)90304-5.
Adjuvant chemotherapy with cyclophosphamide, 5-fluorouracil and methotrexate (CMF)-induced permanent ovarian suppression in 47 of 77 (61%) premenopausal patients with axillary node positive breast cancer. After a median observation time of 37 months the relapse-free and overall survival times were significantly longer for patients with permanent amenorrhoea. A strongly positive correlation between CMF-induced amenorrhoea and age of the patients, as well as between age and the tumour PgR status, was found. The induction of ovarian suppression predominantly occurs in patients with PgR positive tumours and may add an endocrine effect to the cytotoxic action of adjuvant chemotherapy in this particular group of older premenopausal women.
环磷酰胺、5-氟尿嘧啶和甲氨蝶呤辅助化疗（CMF）导致77例绝经前腋窝淋巴结阳性乳腺癌患者中的47例（61%）出现永久性卵巢抑制。中位观察时间37个月后，永久性闭经患者的无复发生存期和总生存期显著更长。发现CMF诱导的闭经与患者年龄以及年龄与肿瘤孕激素受体（PgR）状态之间存在强正相关。卵巢抑制的诱导主要发生在PgR阳性肿瘤患者中，这可能会给这一特定组老年绝经前女性辅助化疗的细胞毒性作用增加一种内分泌效应。
