氯化镉通过激活辣椒素敏感的感觉神经诱导大鼠离体膀胱收缩。
Cadmium chloride induces contractions of the rat isolated urinary bladder by activation of capsaicin-sensitive sensory nerves.
作者信息
Patacchini R, Santicioli P, Giuliani S, Maggi C A, Meli A
机构信息
Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.
出版信息
Eur J Pharmacol. 1988 Apr 13;148(3):449-52. doi: 10.1016/0014-2999(88)90126-4.
Cadmium chloride (CdCl2)(30 microM-1 mM) produced a concentration-related contraction of the rat isolated urinary bladder which was abolished by tetrodotoxin (1 microM) or extrinsic bladder denervation (72 h before). Complete cross-desensitization was observed between the contractile response to Cd and capsaicin, indicating that, at the peripheral level, this inorganic calcium channel blocker can activate the 'efferent' function of capsaicin-sensitive sensory nerves.
氯化镉（CdCl2）（30微摩尔 - 1毫摩尔）可使大鼠离体膀胱产生浓度依赖性收缩，这种收缩可被河豚毒素（1微摩尔）或膀胱去神经支配（72小时前）所消除。对镉和辣椒素的收缩反应之间观察到完全交叉脱敏，这表明在外周水平，这种无机钙通道阻滞剂可激活辣椒素敏感感觉神经的“传出”功能。
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