Forensic Department, Assistance Publique-Hôpitaux de Marseille, La Timone, 264, rue St Pierre, 13385 Marseille Cedex 05, France; Aix Marseille Univ, CNRS, EFS, ADES, Marseille, France.
Aix Marseille Univ, CNRS, EFS, ADES, Marseille, France.
Morphologie. 2022 Jun;106(353):98-106. doi: 10.1016/j.morpho.2021.03.006. Epub 2021 Apr 8.
The integration of the growth of the brain and the cranial base suggests that each system may influence the other, notably during the first three years of life, although this influence has never been proven to be exclusive. The aim of our work was to analyse the dynamics of normal growth on the one hand, and the development and ontogenetic allometry of the cranial base in the infant on the other hand.
A total of 32 infants (17 males/15 femeles) having been included in the unexpected infant death french protocol were analyzed. Three-dimensional reconstructions of the cranial base were performed from CT scans. The technique combined manual segmentation of regions of interest, contour extraction and surface reconstruction. Nineteen landmarks were positioned on each of the bone surfaces.
No correlation was observed between sex assigned at birth and shape, weight, crown-heel length, or head circumference. Principal component analysis showed that 85.5% of the variance observed on the first component was secondary to growth. After Procrustes superimposition, 25% of the shape variance observed was explained by the first principal component. It showed anteroposterior lengthening of the cranial base. In addition, the height, width and length of the posterior fossa increased and the relative position of the basion was displaced inferiorly and anteriorly with flexion of the sphenoid angle. Negative allometry was also observed.
Our study, carried out in a rigorously selected population of infants, presents a fundamental approach to ontogeny through study of shape, growth and ontogenetic allometry.
大脑和颅底的生长是相互关联的，这表明每个系统都可能影响另一个系统，尤其是在生命的头三年，尽管这种影响从未被证明是排他性的。我们的工作旨在分析正常生长的动力学，一方面是颅底的发育和个体发生的比例变化。
总共纳入了 32 名婴儿（17 名男性/15 名女性），这些婴儿都参与了法国意外婴儿死亡研究协议。从 CT 扫描中进行了颅底的三维重建。该技术结合了手动分割感兴趣区域、轮廓提取和表面重建。在每个骨表面上都定位了 19 个标志点。
出生时分配的性别与形状、体重、冠跟长度或头围之间没有相关性。主成分分析表明，在第一成分中观察到的 85.5%的方差是由生长引起的。在 Procrustes 叠加后，观察到的形状方差的 25%可以由第一主成分解释。它显示了颅底的前后延长。此外，后颅窝的高度、宽度和长度增加，蝶骨角度的弯曲使蝶鞍的相对位置向下和向前移位。还观察到负异速生长。
我们的研究在严格选择的婴儿人群中进行，通过研究形状、生长和个体发生的比例变化，提出了一种对个体发生的基本方法。
