Wender M, Adamczewska-Goncerzewicz Z, Stanisławska J, Pankrac J, Talkowska D, Grochowalska A
Department of Neurology, School of Medicine, Poznań, Poland.
Exp Pathol. 1988;33(1):59-63. doi: 10.1016/s0232-1513(88)80058-6.
The pattern of cerebral myelin lipids was studied in Wistar rats exposed to mild hypoxia (7% of oxygen in a respiratory mixture) for 30 min. The most pronounced change involved a marked increase in cholesterol esters and lysophosphatidylcholine content in the myelin fraction. The results obtained indicate that mild hypoxia induces a lesion of myelin membranes but does not provoke the reaction of lymphocytes and macrophages, which by production of myelinolytic factors, evoke demyelination.
研究了暴露于轻度缺氧（呼吸混合气中氧气含量为7%）30分钟的Wistar大鼠脑髓磷脂脂质的模式。最明显的变化是髓磷脂部分中胆固醇酯和溶血磷脂酰胆碱含量显著增加。所得结果表明，轻度缺氧会导致髓磷脂膜损伤，但不会引发淋巴细胞和巨噬细胞的反应，而淋巴细胞和巨噬细胞通过产生髓鞘溶解因子会引发脱髓鞘。
