Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Japan.
Department of Nephrology, Kameda Medical Center, Japan.
Intern Med. 2021 Oct 1;60(19):3125-3128. doi: 10.2169/internalmedicine.6413-20. Epub 2021 Apr 12.
Membranous nephropathy often achieves spontaneous remission. However, there are scarce reports of spontaneous remission of thrombospondin type-1 domain-containing 7A (THSD7A)-associated membranous nephropathy. A 64-year-old female presented with nephrotic syndrome and edema of the lower extremities. We diagnosed membranous nephropathy by kidney biopsy and confirmed positive THSD7A on immunofluorescence using frozen sections; serum THSD7A antibodies were also detected. Thirty-four months after the initial diagnosis, she achieved a spontaneous complete remission without immunosuppressive therapy. With the complete remission, no serum THSD7A levels were detected. In this study, we describe serial examinations of kidney biopsies and serum THSD7A antibodies.
膜性肾病常可自发缓解。然而，THSD7A 相关性膜性肾病自发缓解的报道却很少。一位 64 岁女性因肾病综合征和下肢水肿就诊。我们通过肾活检诊断为膜性肾病，并通过冰冻切片免疫荧光确认 THSD7A 阳性；同时还检测了血清 THSD7A 抗体。初始诊断后 34 个月，患者在未接受免疫抑制治疗的情况下自发完全缓解。完全缓解后，未检测到血清 THSD7A 水平。本研究描述了对肾活检和血清 THSD7A 抗体的连续检查。
