Abdalla Maisa I, Levesque Barrett G
Division of Gastroenterology and Hepatology, University of Rochester Medical Center/Strong Memorial Hospital, Rochester, New York, USA.
Division of Gastroenterology and Hepatology, Los Angeles County Hospital/Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
Am J Gastroenterol. 2021 Jun 1;116(6):1187-1188. doi: 10.14309/ajg.0000000000001261.
With the early success of their trials for the treatment of ulcerative colitis, corticosteroids gained popularity as a treatment for inflammatory bowel disease (IBD). However, when used chronically, corticosteroids are not effective in maintaining remission and associated with toxic effects. Steroid-free remission has become a major treatment goal. Prolonged corticosteroid use is currently a sign of suboptimal quality of care. Trends over the past 2 decades, spanning the emergence of biologic therapies for IBD, are explored here in the University of Manitoba IBD Epidemiologic Database.
随着皮质类固醇在治疗溃疡性结肠炎试验中的早期成功，它们作为炎症性肠病（IBD）的一种治疗方法而受到欢迎。然而，长期使用时，皮质类固醇在维持缓解方面并不有效，且会产生毒性作用。无类固醇缓解已成为主要的治疗目标。目前，长期使用皮质类固醇是护理质量欠佳的一个迹象。本文在曼尼托巴大学IBD流行病学数据库中探讨了过去20年的趋势，这期间IBD生物疗法不断涌现。
