Lussier M, Viens P
Department of Microbiology and Immunology, Faculty of Medicine, University of Montreal, Quebec, Canada.
Exp Biol. 1988;47(3):183-4.
When mice were infected with Trypanosoma musculi during the second week of pregnancy, the level of parasitemia was significantly higher than in controls. Progesterone and estradiol injected daily into normal virgin mice during the course of infection did not modify the parasitemia. Daily injections of low-dose hydrocortisone into infected mice produced elevated parasitemias although these never reached the levels obtained during pregnancy. It is postulated that systemic levels of gestational hormones are only a minor contributing factor for elevated parasitemia.
在怀孕第二周时,若小鼠感染了鼠锥虫,其寄生虫血症水平显著高于对照组。在感染过程中,每天给正常的未交配小鼠注射孕酮和雌二醇,并未改变寄生虫血症水平。给感染小鼠每天注射低剂量氢化可的松,会导致寄生虫血症升高,尽管其水平从未达到怀孕期间的水平。据推测,孕期激素的全身水平只是导致寄生虫血症升高的一个次要因素。