Stone B A, Serafini P C, Batzofin J H, Quinn P, Kerin J F, Marrs R P
Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California.
Fertil Steril. 1988 Jul;50(1):102-9. doi: 10.1016/s0015-0282(16)60016-x.
Follicle development was induced in 41 women with follicle-stimulating hormone (FSH) and human menopausal gonadotropin. Blood samples were drawn and follicular fluids (FF) were aspirated when two or more follicles attained diameters of 15 to 17 mm. Levels of estradiol (E2), progesterone (P), FSH, and luteinizing hormone (LH) were determined in samples by radioimmunoassay, and relationships between the measured parameters in antral fluids and in serum were examined by least-squares linear regression analysis. Levels of LH in serum correlated with LH and FSH levels in FF (P less than 0.005). Concentrations of FSH in serum were positively related to levels of LH, FSH, E2, and total protein in FF (P less than 0.005). E2 levels in serum were predictive of E2 levels in FF only, and levels of P in serum were directly correlated with P levels in FF (P less than 0.05). With respect to the peculiarly broad range of predictions that could be drawn from the FSH content of serum, peripheral FSH provided a better predictive index of the chemical composition of antral fluid than did the level of any other single hormone measured in serum.
对41名女性使用促卵泡激素（FSH）和人绝经期促性腺激素诱导卵泡发育。当两个或更多卵泡直径达到15至17毫米时，采集血样并抽吸卵泡液（FF）。通过放射免疫测定法测定样本中雌二醇（E2）、孕酮（P）、FSH和促黄体生成素（LH）的水平，并通过最小二乘线性回归分析检查窦液和血清中测量参数之间的关系。血清中的LH水平与FF中的LH和FSH水平相关（P小于0.005）。血清中FSH的浓度与FF中的LH、FSH、E2和总蛋白水平呈正相关（P小于0.005）。血清中的E2水平仅可预测FF中的E2水平，血清中的P水平与FF中的P水平直接相关（P小于0.05）。就从血清FSH含量得出的特别广泛的预测范围而言，外周FSH比血清中测量的任何其他单一激素水平更能预测窦液的化学成分。
