Simkhada Nabin, Adhikari Prakash, Baral Nisha, Dhakal Bishal, Mahat Krish
Internal Medicine, Nepalese Army Institute of Health Sciences, Kathmandu, NPL.
Internal Medicine, Piedmont Athens Regional Medical Center, Athens, USA.
Cureus. 2021 Mar 9;13(3):e13776. doi: 10.7759/cureus.13776.
Multiple myeloma (MM) is a clonal proliferation of plasma cells in the bone marrow resulting in the production of paraproteins. It is more common in elderly adults and presents with nonspecific symptoms like bone pain, pathological fracture, fatigue, and signs of hypercalcemia. Peripheral neuropathy is an atypical presentation. We present a rare case of vasculitic neuropathy (VN) who was also diagnosed with MM at the same time. Nerve conduction study and biopsy showed findings suggestive of demyelinating VN. His serum protein electrophoresis and bone marrow aspirate were consistent with MM. The association between these two conditions remains understudied. So far there is no strong evidence suggesting an association between MM and VN. If VN was just coincidental or a presenting symptom of MM remains a question and warrants further studies.
多发性骨髓瘤（MM）是骨髓中浆细胞的克隆性增殖，导致副蛋白的产生。它在老年人中更常见，表现为骨痛、病理性骨折、疲劳和高钙血症体征等非特异性症状。周围神经病变是一种非典型表现。我们报告一例罕见的血管炎性神经病变（VN）患者，其同时也被诊断为MM。神经传导研究和活检显示有脱髓鞘性VN的表现。他的血清蛋白电泳和骨髓穿刺结果与MM一致。这两种疾病之间的关联仍研究不足。到目前为止，没有强有力的证据表明MM与VN之间存在关联。VN是巧合还是MM的一种表现症状仍是一个问题，值得进一步研究。
