Fragola P V, Autore C, Ruscitti G, Picelli A, Borzi M, Cannata D, Sangiorgi M
Department of Internal Medicine, II University of Rome.
G Ital Cardiol. 1988 Jan;18(1):52-4.
Eighty-nine first-degree relatives of 22 patients with an established diagnosis of hypertrophic cardiomyopathy underwent electrocardiographic and echocardiographic screening. Scalar electrocardiogram was abnormal in 30/89 (33.7%) relatives. Of these thirty, eleven had definite evidence of hypertrophic cardiomyopathy at echo; one had borderline hypertrophy and was considered neither affected nor unaffected; four had questionable signs of hypertrophy. The remaining 14 relatives had normal echo-cardiograms. Fifty-nine relatives (66.3%) had normal electrocardiograms; at echo 3 were considered to have borderline hypertrophy, 16 had questionable signs of hypertrophy and 40 were normal. In relatives of patients with hypertrophic cardiomyopathy an abnormal electrocardiogram may reflect different morphologic conditions: a real hypertrophic cardiomyopathy or a myocardial hypertrophy of uncertain significance. Furthermore, in these categories of subjects, an abnormal electrocardiogram with normal echo must be considered with caution.
对22例确诊为肥厚型心肌病患者的89名一级亲属进行了心电图和超声心动图筛查。89名亲属中30人（33.7%）的体表心电图异常。在这30人中，11人在超声心动图检查时有明确的肥厚型心肌病证据；1人有临界性肥厚，被认为既未患病也未未患病；4人有可疑的肥厚迹象。其余14名亲属的超声心动图正常。59名亲属（66.3%）心电图正常；在超声心动图检查中，3人被认为有临界性肥厚，16人有可疑的肥厚迹象，40人正常。在肥厚型心肌病患者的亲属中，异常心电图可能反映不同的形态学情况：真正的肥厚型心肌病或意义不确定的心肌肥厚。此外，在这些受试者类别中，对于心电图异常而超声心动图正常的情况必须谨慎考虑。
