Department of Histology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, ul. Medyków 18, 40-752, Katowice, Poland.
Clinic of Psychiatric Rehabilitation, Department of Psychiatry and Psychotherapy, Faculty of Medical Sciences in Katowice, Medical University of Silesia, ul. Ziołowa 45/47, 40-635, Katowice, Poland.
Pharmacol Rep. 2021 Aug;73(4):1164-1169. doi: 10.1007/s43440-021-00259-7. Epub 2021 Apr 12.
Adult neurogenesis observed both in the subventricular zone (SVZ) and hippocampus may be regulated and modulated by several endogenous factors, xenobiotics and medications. Classical and atypical antipsychotic drugs are able to affect neuronal and glial cell proliferation in the rat brain. The main purpose of this structural study was to determine whether chronic chlorpromazine treatment affects adult neurogenesis in the canonical sites of the rat brain. At present, the clinical application of chlorpromazine is rather limited; however, it may still represent an important model in basic neuropharmacological and toxicological studies.
The number of neural progenitors and immature neurons was enumerated using immunofluorescent detection of Sox2, Musashi1 and doublecortin (DCX) expression within SVZ.
Chlorpromazine has a depressive effect on the early phase of adult neurogenesis in the rat subventricular zone (SVZ), as the mean number of Sox-2 immunoexpressing cells decreased following treatment.
Collectively, these results may suggest that long-term treatment with chlorpromazine may decrease neurogenic stem/progenitor cell formation in the rat SVZ and may affect rostral migratory stream formation.
成年神经发生在侧脑室下区（SVZ）和海马体中都有观察到，可能受到多种内源性因子、外源性物质和药物的调节和影响。经典和非典型抗精神病药物能够影响大鼠大脑中神经元和神经胶质细胞的增殖。这项结构研究的主要目的是确定慢性氯丙嗪治疗是否会影响大鼠大脑中经典部位的成年神经发生。目前，氯丙嗪的临床应用相当有限；然而，它在基础神经药理学和毒理学研究中仍可能是一个重要的模型。
通过免疫荧光检测 Sox2、Musashi1 和双皮质素（DCX）的表达，对 SVZ 中的神经前体细胞和未成熟神经元的数量进行计数。
氯丙嗪对大鼠侧脑室下区（SVZ）的成年神经发生早期阶段具有抑制作用，因为治疗后 Sox-2 免疫反应细胞的平均数量减少。
总的来说，这些结果可能表明，长期氯丙嗪治疗可能会减少大鼠 SVZ 中的神经发生干细胞/祖细胞的形成，并可能影响前脑迁移流的形成。
