Department of Histology, School of Medicine in Katowice, Medical University of Silesia, ul. Medykow 18, 40-752, Katowice, Poland.
Unidad de Trastornos del Movimiento y Sueno/Centro de Innovacion Medica Aplicada, Hospital General Dr. Manuel Gea Gonzalez, Mexico City, Mexico.
CNS Neurol Disord Drug Targets. 2018;17(6):458-463. doi: 10.2174/1871527317666180627113544.
BACKGROUND & OBJECTIVE: Continuously active neurogenic regions in the adult brain are located in the subventricular zone (SVZ) of the lateral ventricles and subgranular zone of the hippocampal dentate gyrus. Neurogenesis is modulated by many factors such as growth factors, neurotransmitters and hormones. Neuropsychiatric drugs, especially antidepressants, mood stabilizers and antipsychotics may also affect the origin of neuronal cells.
The purpose of this study was to determine the effects of chronic olanzapine treatment on adult rat neurogenesis at the level of the SVZ. The number of neuroblasts was evaluated using immunohistochemical and fluorescent detection of sex determining region Y-box 2 and doublecortin expressing cells.
RESULTS & CONCLUSION: The results indicate that olanzapine has proneurogenic effects on the adult rat SVZ, as the mean number of sex determining region Y-box 2 and doublecortin-positive cells increased significantly, while there was a similar tendency in the subgranular zone. Collectively, these results suggest that long-term treatment with olanzapine may stimulate neurogenic stem cell formation in the SVZ which supports adult neurogenesis.
成年大脑中持续活跃的神经发生区域位于侧脑室的室下区（SVZ）和海马齿状回的颗粒下区。神经发生受多种因素的调节，如生长因子、神经递质和激素。神经精神药物，特别是抗抑郁药、心境稳定剂和抗精神病药，也可能影响神经元细胞的起源。
本研究旨在确定慢性奥氮平治疗对 SVZ 水平成年大鼠神经发生的影响。使用性别决定区 Y 框 2 和双皮质素表达细胞的免疫组织化学和荧光检测来评估神经母细胞的数量。
结果表明，奥氮平对成年大鼠 SVZ 具有促神经发生作用，因为性别决定区 Y 框 2 和双皮质素阳性细胞的平均数量显著增加，而颗粒下区也有类似的趋势。综上所述，这些结果表明，长期奥氮平治疗可能刺激 SVZ 中的神经发生干细胞形成，从而支持成年神经发生。
