School of Health Sciences, Istanbul Gelisim University, Istanbul, Turkey.
Department of Physical Medicine and Rehabilitation, Private Nisa Hospital, Istanbul, Turkey.
J Back Musculoskelet Rehabil. 2021;34(5):725-733. doi: 10.3233/BMR-200194.
In this study we investigate the effects of paravertebral ozone injections (POI), which have been used as a new treatment approach for lower back pain in recent years, on pain and physical activity in patients with acute lumbar disc herniation (LDH) as an additional treatment.
Thirty-eight patients were assigned into the ozone therapy (OT) group (n= 20) and placebo control (PC) group (n= 18). Both groups received two sessions per week, a total of 8 sessions of lumbar POI. The ozone concentrations of 20-25 μg/ml (30 ml) and 0.1 μg/ml (30 ml) were administered to the OT and PC groups, respectively. The patients were assessed with the visual analog scale (VAS) and Oswestry Disability Index (ODI) before the treatment (V1), 15 (V2) and 30 (V3) days after the treatment started, and one month (V4) after the treatment ended.
A significant improvement was seen in the VAS and ODI scores in the final follow-up (V4) as compared with the baselines scores (V1) in both groups (P< 0.05). The patients in the OT group had lower mean VAS and ODI scores in V2, V3, and V4 follow-ups compared with the patients in the PC group. This significant difference reached its peak in the final follow-up (V4) (P< 0.05).
As an additional treatment combined with conservative treatment, lumbar POI can lessen pain and disability in patients with acute LDH.
本研究旨在探讨近年来作为一种新的腰痛治疗方法的椎旁臭氧注射（POI）对急性腰椎间盘突出症（LDH）患者疼痛和身体活动的影响。
将 38 名患者分为臭氧治疗（OT）组（n=20）和安慰剂对照组（PC）组（n=18）。两组均每周接受两次治疗，共进行 8 次腰椎 POI。OT 组给予 20-25μg/ml（30ml）臭氧浓度，PC 组给予 0.1μg/ml（30ml）臭氧浓度。在治疗前（V1）、治疗开始后 15 天（V2）、30 天（V3）和治疗结束后 1 个月（V4），采用视觉模拟评分（VAS）和 Oswestry 功能障碍指数（ODI）对患者进行评估。
两组患者在最终随访（V4）时的 VAS 和 ODI 评分均较基线水平（V1）显著改善（P<0.05）。OT 组患者在 V2、V3 和 V4 随访时的 VAS 和 ODI 评分均低于 PC 组患者，这种显著差异在最终随访（V4）时达到高峰（P<0.05）。
作为一种联合保守治疗的附加治疗，腰椎 POI 可以减轻急性 LDH 患者的疼痛和残疾。
