在悉尼癌症生存者诊所就诊的乳腺癌幸存者中，睡眠障碍、症状与饮酒之间的关系。

Relationship between sleep disturbance, symptoms, and alcohol use in breast cancer survivors attending Sydney Cancer Survivorship Clinic.

机构信息

Concord Cancer Centre, Concord Repatriation General Hospital, Concord, New South Wales, Australia.

Concord Clinical School, University of Sydney, Sydney, New South Wales, Australia.

出版信息

Support Care Cancer. 2021 Nov;29(11):6233-6242. doi: 10.1007/s00520-021-06176-y. Epub 2021 Apr 12.

DOI:10.1007/s00520-021-06176-y

PMID:33844082

Abstract

PURPOSE

We sought to determine the association between 'trouble sleeping', alcohol intake, hot flashes, and quality of life (QOL) in early-stage breast cancer survivors attending the Sydney Cancer Survivorship Clinic (SCSC).

METHODS

Survivors who had completed primary adjuvant treatment completed questionnaires assessing the following: symptoms, QOL (mean global score on FACT-G), and alcohol intake (drinks per day for past week), on the first visit to SCSC. Trouble sleeping and hot flashes were scored from 0 (no trouble at all) to 10 (worst I can imagine), with scores ≥ 4 classified as at least moderate and ≥ 7 severe.

RESULTS

238 breast cancer survivors attended SCSC from September 2013 to May 2019, with data available for 227 (median age 53 years; 70% on endocrine therapy). Trouble sleeping was at least moderate in 54% and severe in 19%. 47% reported consuming alcohol (mean 4.9 drinks/week). Scores for trouble sleeping were no different between survivors reporting alcohol consumption and not (mean 4.13 vs. 3.6; p = 0.17). Survivors reporting at least moderate trouble sleeping (vs. less than moderate) were no more likely to drink alcohol (OR 1.74, 95% CI 0.96-3.14, p = 0.067) but had poorer mean QOL scores (69.1 vs. 78.3; p = 0.0006). Survivors reporting at least moderate hot flashes (vs. less than moderate) were more likely to report at least moderate trouble sleeping (OR 3.78, 95% CI 2.02-6.71, p < 0.0001) and had worse mean QOL scores (68 vs. 78; p = 0.001).

CONCLUSION

Trouble sleeping is common amongst breast cancer survivors and associated with hot flashes and poorer QOL, but not with self-reported alcohol consumption.

摘要

目的

我们旨在探讨在参加悉尼癌症康复诊所（SCSC）的早期乳腺癌幸存者中，“睡眠困难”、饮酒、热潮红与生活质量（QOL）之间的关系。

方法

完成辅助治疗的幸存者在首次就诊 SCSC 时，完成了以下问卷评估：症状、QOL（FACT-G 平均总分）和饮酒量（过去一周的饮酒量）。睡眠困难和热潮红的评分范围为 0（一点也不麻烦）到 10（我能想象到的最糟糕的情况），评分≥4 被归类为至少中度，评分≥7 为严重。

结果

2013 年 9 月至 2019 年 5 月，有 238 名乳腺癌幸存者参加了 SCSC，其中 227 名（中位年龄 53 岁；70%接受内分泌治疗）的数据可用。至少有 54%的人存在中度及以上睡眠困难，19%的人存在严重睡眠困难。47%的人报告饮酒（平均每周 4.9 杯）。报告饮酒和不饮酒的幸存者之间，睡眠困难评分没有差异（平均 4.13 与 3.6；p=0.17）。与中度以下睡眠困难相比，报告至少中度睡眠困难的幸存者饮酒的可能性更小（OR 1.74，95%CI 0.96-3.14，p=0.067），但 QOL 评分均值更低（69.1 与 78.3；p=0.0006）。报告至少中度热潮红的幸存者（与低于中度的相比）更有可能报告至少中度睡眠困难（OR 3.78，95%CI 2.02-6.71，p<0.0001），且 QOL 评分均值更差（68 与 78；p=0.001）。