Concord Cancer Centre, Concord Repatriation General Hospital, Concord, New South Wales, Australia.
Concord Clinical School, University of Sydney, Sydney, New South Wales, Australia.
Support Care Cancer. 2021 Nov;29(11):6233-6242. doi: 10.1007/s00520-021-06176-y. Epub 2021 Apr 12.
We sought to determine the association between 'trouble sleeping', alcohol intake, hot flashes, and quality of life (QOL) in early-stage breast cancer survivors attending the Sydney Cancer Survivorship Clinic (SCSC).
Survivors who had completed primary adjuvant treatment completed questionnaires assessing the following: symptoms, QOL (mean global score on FACT-G), and alcohol intake (drinks per day for past week), on the first visit to SCSC. Trouble sleeping and hot flashes were scored from 0 (no trouble at all) to 10 (worst I can imagine), with scores ≥ 4 classified as at least moderate and ≥ 7 severe.
238 breast cancer survivors attended SCSC from September 2013 to May 2019, with data available for 227 (median age 53 years; 70% on endocrine therapy). Trouble sleeping was at least moderate in 54% and severe in 19%. 47% reported consuming alcohol (mean 4.9 drinks/week). Scores for trouble sleeping were no different between survivors reporting alcohol consumption and not (mean 4.13 vs. 3.6; p = 0.17). Survivors reporting at least moderate trouble sleeping (vs. less than moderate) were no more likely to drink alcohol (OR 1.74, 95% CI 0.96-3.14, p = 0.067) but had poorer mean QOL scores (69.1 vs. 78.3; p = 0.0006). Survivors reporting at least moderate hot flashes (vs. less than moderate) were more likely to report at least moderate trouble sleeping (OR 3.78, 95% CI 2.02-6.71, p < 0.0001) and had worse mean QOL scores (68 vs. 78; p = 0.001).
Trouble sleeping is common amongst breast cancer survivors and associated with hot flashes and poorer QOL, but not with self-reported alcohol consumption.
我们旨在探讨在参加悉尼癌症康复诊所（SCSC）的早期乳腺癌幸存者中，“睡眠困难”、饮酒、热潮红与生活质量（QOL）之间的关系。
完成辅助治疗的幸存者在首次就诊 SCSC 时，完成了以下问卷评估：症状、QOL（FACT-G 平均总分）和饮酒量（过去一周的饮酒量）。睡眠困难和热潮红的评分范围为 0（一点也不麻烦）到 10（我能想象到的最糟糕的情况），评分≥4 被归类为至少中度，评分≥7 为严重。
2013 年 9 月至 2019 年 5 月，有 238 名乳腺癌幸存者参加了 SCSC，其中 227 名（中位年龄 53 岁；70%接受内分泌治疗）的数据可用。至少有 54%的人存在中度及以上睡眠困难，19%的人存在严重睡眠困难。47%的人报告饮酒（平均每周 4.9 杯）。报告饮酒和不饮酒的幸存者之间，睡眠困难评分没有差异（平均 4.13 与 3.6；p=0.17）。与中度以下睡眠困难相比，报告至少中度睡眠困难的幸存者饮酒的可能性更小（OR 1.74，95%CI 0.96-3.14，p=0.067），但 QOL 评分均值更低（69.1 与 78.3；p=0.0006）。报告至少中度热潮红的幸存者（与低于中度的相比）更有可能报告至少中度睡眠困难（OR 3.78，95%CI 2.02-6.71，p<0.0001），且 QOL 评分均值更差（68 与 78；p=0.001）。
睡眠困难在乳腺癌幸存者中很常见，与热潮红和较差的 QOL 相关，而与自我报告的饮酒量无关。
