Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai, China 200062.
J Org Chem. 2021 May 7;86(9):6847-6854. doi: 10.1021/acs.joc.0c02413. Epub 2021 Apr 12.
A Pd-catalyzed multicomponent reaction was developed by trapping oxomium ylide with nitrosobenzene via Pd-promoted umpolung chemistry. The Pd catalyst plays two important roles: diazo compound decomposed catalyst and Lewis acid for the activation of nitrosobenzene. This strategy provides some insight into a new way for discovery of multicomponent methodology to construct complex molecules. The developed method also provides rapid access to a series of -(2-oxy) hydroxylamine derivatives, which exhibit good anticancer activity in osteosarcoma cells.
Pd 催化的多组分反应通过 Pd 促进的反转化学作用将氧化锇叶立德与亚硝基苯捕获，从而得以开发。Pd 催化剂发挥了两个重要作用：重氮化合物分解催化剂和路易斯酸，用于激活亚硝基苯。该策略为发现多组分方法构建复杂分子提供了新的思路。所开发的方法还可以快速获得一系列-（2-氧基）羟胺衍生物，它们在骨肉瘤细胞中表现出良好的抗癌活性。
