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胸外科医师学会 2021 年成人心脏手术多瓣膜手术风险模型。

The Society of Thoracic Surgeons 2021 Adult Cardiac Surgery Risk Models for Multiple Valve Operations.

机构信息

Congenital Heart Center, Division of Cardiovascular Surgery, Department of Surgery, University of Florida, Gainesville, Florida.

Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

出版信息

Ann Thorac Surg. 2022 Feb;113(2):511-518. doi: 10.1016/j.athoracsur.2021.03.089. Epub 2021 Aug 5.

Abstract

BACKGROUND

The Society of Thoracic Surgeons (STS) Quality Measurement Task Force has developed risk models and composite performance measures for isolated coronary artery bypass grafting (CABG), isolated aortic valve replacement (AVR), isolated mitral valve replacement or repair (MVRR), AVR+CABG, and MVRR+CABG. To further enhance its portfolio of risk-adjusted performance metrics, STS has developed new risk models for multiple valve operations ± CABG procedures.

METHODS

Using July 2011 to June 2019 STS Adult Cardiac Surgery Database data, risk models for AVR+MVRR (n = 31,968) and AVR+MVRR+CABG (n = 12,650) were developed with the following endpoints: Operative Mortality, major morbidity (any 1 or more of the following: cardiac reoperation, deep sternal wound infection/mediastinitis, stroke, prolonged ventilation, and renal failure), and combined mortality and/or major morbidity. Data were divided into development (July 2011 to June 2017; n = 35,109) and validation (July 2017 to June 2019; n = 9509) samples. Predictors were selected by assessing model performance and clinical face validity of full and progressively more parsimonious models. Performance of the resulting models was evaluated by assessing discrimination and calibration.

RESULTS

C-statistics for the overall population of multiple valve ± CABG procedures were 0.7086, 0.6734, and 0.6840 for mortality, morbidity, and combined mortality and/or morbidity in the development sample, and 0.6953, 0.6561, and 0.6634 for the same outcomes, respectively, in the validation sample.

CONCLUSIONS

New STS Adult Cardiac Surgery Database risk models have been developed for multiple valve ± CABG operations, and these models will be used in subsequent STS performance metrics.

摘要

背景

胸外科医师学会(STS)质量测量工作组已经为单纯冠状动脉旁路移植术(CABG)、单纯主动脉瓣置换术(AVR)、单纯二尖瓣置换或修复术(MVRR)、AVR+CABG 和 MVRR+CABG 制定了风险模型和综合绩效指标。为了进一步增强其风险调整后绩效指标组合,STS 已经为多瓣膜手术±CABG 手术开发了新的风险模型。

方法

使用 2011 年 7 月至 2019 年 6 月 STS 成人心脏外科学数据库的数据,开发了 AVR+MVRR(n=31968)和 AVR+MVRR+CABG(n=12650)的风险模型,其终点为手术死亡率、主要发病率(任何 1 种或多种以下情况:心脏再次手术、深部胸骨伤口感染/纵隔炎、中风、长时间通气和肾衰竭)以及死亡率和/或主要发病率的合并。数据分为开发(2011 年 7 月至 2017 年 6 月;n=35109)和验证(2017 年 7 月至 2019 年 6 月;n=9509)样本。通过评估全模型和逐步更简约模型的性能和临床有效性来选择预测因子。通过评估区分度和校准度来评估所得模型的性能。

结果

多瓣膜±CABG 手术患者总体人群的 C 统计量在开发样本中分别为死亡率、发病率和死亡率和/或发病率合并的 0.7086、0.6734 和 0.6840,在验证样本中分别为 0.6953、0.6561 和 0.6634。

结论

STS 成人心脏外科学数据库已为多瓣膜±CABG 手术开发了新的风险模型,这些模型将用于随后的 STS 绩效指标中。

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