Department of Psychology, University of Guelph, Ontario N1G 2W1, Canada.
Department of Psychology, University of Guelph, Ontario N1G 2W1, Canada.
Pharmacol Biochem Behav. 2021 Jun;205:173189. doi: 10.1016/j.pbb.2021.173189. Epub 2021 Apr 15.
There are indications that sugars in the diet can play a role in vulnerability to opioid abuse. The current study examined a range of neuro-behavioural interactions between oxycodone (OXY) and high fructose corn syrup (HFCS). Male Sprague-Dawley rats had access to HFCS (0 or 50%) over 26 days in their home cages and were subsequently tested on place conditioning induced by 0, 0.16 and 2.5 mg/kg OXY (3 pairings of drug and saline, each 30 min), as well as on locomotor responses to 0, 0.16 and 2.5 mg/kg OXY, and in-vivo microdialysis was employed to measure dopamine (DA) levels in the nucleus accumbens (NAc) in response to 0 and 2.5 mg/kg OXY. A complex set of interactions between HFCS exposure and responses to OXY were observed: HFCS increased place preference induced by OXY, it enhanced the suppressant effect of OXY on locomotion, and it attenuated OXY-induced elevation in DA overflow in the NAc. Taken together, these findings suggest that nutrition has the potential to influence some responses to opioids which may be relevant to their abuse.
有迹象表明，饮食中的糖可能在易患阿片类药物滥用方面发挥作用。本研究考察了羟考酮 (OXY) 和高果糖玉米糖浆 (HFCS) 之间一系列神经行为相互作用。雄性 Sprague-Dawley 大鼠在其家笼中可自由接触 HFCS（0 或 50%）26 天，随后在 0、0.16 和 2.5 mg/kg OXY 诱导的位置条件作用下进行测试（药物和盐水各 3 对，每次 30 分钟），以及对 0、0.16 和 2.5 mg/kg OXY 的运动反应，以及体内微透析用于测量核仁 accumbens (NAc) 中 0 和 2.5 mg/kg OXY 对多巴胺 (DA) 水平的影响。观察到 HFCS 暴露与 OXY 反应之间存在一系列复杂的相互作用：HFCS 增加了 OXY 诱导的位置偏好，增强了 OXY 对运动的抑制作用，并减弱了 OXY 诱导的 NAc 中 DA 溢出的升高。总之，这些发现表明，营养有可能影响对阿片类药物的一些反应，这可能与其滥用有关。
