Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.
Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.
Int J Pharm. 2021 May 15;601:120589. doi: 10.1016/j.ijpharm.2021.120589. Epub 2021 Apr 15.
Hyaluronic acid has become an interesting and important polymer as an excipient for pharmaceutical products due to its beneficial properties, like solubility, biocompatibility and biodegradation. To improve the properties of hyaluronic acid, different possibilities for chemical modifications are presented, and the opportunities as novel systems for drug delivery are discussed. This review gives an overview over the production of hyaluronic acid, the possibilities of its chemical modification and the current state of in vitro and in vivo research. Furthermore, market approved and commercially available products are reviewed and derivatives undergoing clinical trials and applying for market approval are shown. In particular, hyaluronic acid has been studied for different administrations in rheumatology, ophthalmology, local anesthetics, cancer treatment and bioengineering of tissues. The present work concludes with perspectives for future administration of pharmaceuticals based on hyaluronic acid.
透明质酸因其具有良好的水溶性、生物相容性和可生物降解性等特性，已成为一种有趣且重要的药用辅料聚合物。为了改善透明质酸的性能，人们提出了许多化学修饰的可能性，并探讨了其作为新型药物传递系统的应用。本文综述了透明质酸的生产、化学修饰的可能性以及目前在体外和体内研究的现状。此外，还对已上市的产品进行了综述，并介绍了正在进行临床试验和申请上市的衍生物。特别是，透明质酸在风湿病学、眼科学、局部麻醉剂、癌症治疗和组织生物工程等不同给药途径方面已有研究。本文最后对基于透明质酸的药物未来给药途径进行了展望。
