根据 HIV-1 亚型以及 HIV RNA 在中枢神经系统和血浆中的分布模式，HIV 相关性神经认知障碍（HAND）患者的 IgG 鞘内合成。
IgG intrathecal synthesis in HIV-associated neurocognitive disorder (HAND) according to the HIV-1 subtypes and pattern of HIV RNA in CNS and plasma compartments.
机构信息
Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
出版信息
J Neuroimmunol. 2021 Jun 15;355:577542. doi: 10.1016/j.jneuroim.2021.577542. Epub 2021 Mar 8.
We hypothesized that humoral immunity stimulation in the CNS in HIV-1C patients would be lower than that in HIV-1B due to a defective Tat chemokine dimotif (C30C31) that might influence cellular trafficking and CNS inflammation. Sixty-eight paired CSF and blood samples from people with HIV (PWH), free of CNS opportunistic infections, were included, HIV-1B (n = 27), HIV-1C (n = 26), and HIV negative (n = 25). IgG intrathecal synthesis was assayed using quantitative and qualitative methods. IgG oligoclonal bands (OCB) in CSF were observed in 51% of PWH, comparable between HIV-1B and HIV-1C, as well as the medians of IgG intrathecal synthesis formulas. The group with HIV infection aviremic in CSF and blood showed 75% of OCB. There was a poor positive correlation between the IgG quotient and GDS. The impact of HIV-1 on IgG intrathecal production was not subtype dependent. Low-grade CNS intrathecal IgG production persists in HIV CNS infection even in PWH with CSF and blood HIV RNA controlled.
我们假设，由于 Tat 趋化因子二聚体（C30C31）的缺陷，HIV-1C 患者中枢神经系统中的体液免疫刺激会低于 HIV-1B，这可能会影响细胞运输和中枢神经系统炎症。研究纳入了 68 对来自 HIV 感染者（PWH）的脑脊液和血液样本，这些患者无中枢神经系统机会性感染，分为 HIV-1B（n=27）、HIV-1C（n=26）和 HIV 阴性（n=25）三组。使用定量和定性方法检测 IgG 鞘内合成。51%的 PWH 出现了 CSF 中的 IgG 寡克隆带（OCB），HIV-1B 和 HIV-1C 之间没有差异，IgG 鞘内合成公式的中位数也没有差异。在脑脊液和血液中 HIV 感染病毒载量均为阴性的患者中，75%出现了 OCB。IgG 商和 GDS 之间存在微弱的正相关。HIV-1 对 IgG 鞘内产生的影响与亚型无关。即使在 HIV 中枢神经系统感染的 PWH 中，CSF 和血液中的 HIV RNA 得到控制，低度中枢神经系统 IgG 鞘内产生仍持续存在。
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