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限食对基因肥胖(ob/ob)小鼠冷暴露期间产热和体温调节的影响。

The effect of limit feeding on thermogenesis and thermoregulation in genetically obese (ob/ob) mice during cold exposure.

作者信息

Vinter J, Hull D, Batt R A, Tyler D D

机构信息

Department of Child Health, University Hospital, Nottingham, UK.

出版信息

Int J Obes. 1988;12(2):111-7.

PMID:3384557
Abstract

Thermogenesis and thermoregulation in ad-lib-fed and limit-fed lean (+/ob or +/+) and obese (ob/ob) mice during acute cold exposure were studied by measuring oxygen consumption and body temperature. No significant differences in oxygen consumption were found between the lean ad-lib, obese ad-lib- or obese limit-fed groups. The oxygen consumption of the lean-limit-fed group was decreased by 25-30 per cent compared with the other groups. The body temperature of the obese ad-lib-fed group fell at a rate of at least twice that of any other group. The weight, total cytochrome c oxidase activity and protein content of the brown adipose tissue (BAT) of the lean groups was similar, and there appeared to be little difference in cell size or fat content. The BAT of both obese groups showed a several-fold increase in weight, and a 50 per cent increase in total protein, compared with the lean groups. The limit-fed obese group showed a significant increase in cytochrome c oxidase activity compared with all other groups. The BAT cells of both obese groups were much enlarged and contained considerable amounts of fat. These observations indicate that the susceptibility of obese mice to hypothermia is not due to a reduced capacity for thermogenesis, but to a failure to conserve heat. Failure of thermoregulation in obese animals may be due to postural constraints that result in increased heat loss by radiation. The results are discussed in relation to the accredited role of BAT thermogenesis in rodents exposed to the cold.

摘要

通过测量氧气消耗量和体温,研究了自由采食和限食的瘦小鼠(+/ob或+/+)以及肥胖小鼠(ob/ob)在急性冷暴露期间的产热和体温调节情况。自由采食的瘦小鼠组、自由采食的肥胖小鼠组和限食的肥胖小鼠组之间的氧气消耗量没有显著差异。与其他组相比,限食的瘦小鼠组的氧气消耗量降低了25%至30%。自由采食的肥胖小鼠组的体温下降速度至少是其他任何组的两倍。瘦小鼠组棕色脂肪组织(BAT)的重量、总细胞色素c氧化酶活性和蛋白质含量相似,细胞大小或脂肪含量似乎也没有太大差异。与瘦小鼠组相比,两个肥胖小鼠组的BAT重量均增加了几倍,总蛋白增加了50%。与所有其他组相比,限食的肥胖小鼠组的细胞色素c氧化酶活性显著增加。两个肥胖小鼠组的BAT细胞都明显增大,含有大量脂肪。这些观察结果表明,肥胖小鼠对体温过低的易感性不是由于产热能力降低,而是由于无法保存热量。肥胖动物体温调节失败可能是由于姿势受限,导致辐射散热增加。结合BAT产热在暴露于寒冷环境的啮齿动物中的公认作用对结果进行了讨论。

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