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镉对蛋白质限制饮食大鼠蛋白质-抗坏血酸代谢的影响。

Effect of cadmium on protein-ascorbate metabolism in the protein restricted rat.

作者信息

Pharikal K, Das P C, Dasgupta S

机构信息

University College of Science & Technology, Biochemistry and Nutrition Research Laboratory, Calcutta, India.

出版信息

Int J Vitam Nutr Res. 1988;58(1):79-83.

PMID:3384589
Abstract

Daily administration of cadmium chloride (0.3 mg/100 g of body weight) subcutaneously for 14 days in adult Sprague-Dawley rats led to a decrease in the concentration of protein and ascorbic acid in the liver, plasma and brain regions both in normal protein and in protein restricted dietary condition. Therefore, it might be presumed that the changes in protein and ascorbic acid in both the experimental animal groups alters the metabolic state of the brain affecting neuronal activity.

摘要

在成年斯普拉格-道利大鼠中,皮下每日注射氯化镉(0.3毫克/100克体重),持续14天,无论是在正常蛋白质饮食还是蛋白质限制饮食条件下,都会导致肝脏、血浆和脑区中蛋白质和抗坏血酸浓度降低。因此,可以推测,两个实验动物组中蛋白质和抗坏血酸的变化改变了大脑的代谢状态,影响了神经元活动。

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