Division of Gastroenterology, P D Hinduja Hospital, Mumbai 400016, India.
Division of Gastroenterology, P D Hinduja Hospital, Mumbai 400016, India.
Indian J Tuberc. 2021 Apr;68(2):210-214. doi: 10.1016/j.ijtb.2020.08.010. Epub 2020 Aug 26.
The relationship between the incidence of intestinal tuberculosis (TB) and Crohn's disease (CD) is interesting, especially considering the striking similarity between the two conditions. Some studies from Asian populations suggested that the incidence of intestinal TB decreases when there is an increase in CD.
To compare the incidence trend between intestinal TB and CD over 15 years.
Medical records of patients seen in the Division of Gastroenterology over 15 years (2005-2019) were reviewed. CD was diagnosed according to the Copenhagen criteria. Intestinal TB was diagnosed in the appropriate clinical situation if any one or more of the following was present: (1) positive TB MGIT culture; (2) positive Gene Xpert for TB; (3) suggestive histologic findings, with positive tissue acid-fast bacillus (AFB) on smear or with sustained response to anti-TB therapy. The incidence time trend of patients with CD and intestinal TB diagnosis was then studied year-wise.
632 medical case records were accessed; 60 patients were excluded due to inadequate data or not fulfilling diagnostic criteria. The 572 patients included 224 with intestinal TB (median age 37 years, IQR 22; 125 [56%] females) and 348 with CD (median age 40 years, IQR 25; 159 [46%] females [p < 0.02 as compared to TB]). Thus, more patients with CD were seen during the study period, but there was no correlation between the incidence of the two conditions (r = 0.318; p = 0.25).
In Indian patients in a single private-sector center, there was no inverse correlation between the incidence of intestinal TB and CD over 15 years.
肠结核（TB）和克罗恩病（CD）的发病率之间存在有趣的关系，尤其是考虑到这两种疾病的惊人相似之处。一些来自亚洲人群的研究表明，CD 发病率增加时，肠 TB 的发病率会下降。
比较 15 年来肠 TB 和 CD 的发病率趋势。
回顾 15 年来（2005-2019 年）在消化内科就诊的患者的病历。CD 根据哥本哈根标准诊断。在适当的临床情况下诊断肠 TB，如果符合以下一项或多项标准：（1）TB MGIT 培养阳性；（2）Gene Xpert 检测 TB 阳性；（3）组织学检查提示，抗酸杆菌（AFB）涂片阳性或抗 TB 治疗有持续反应。然后研究 CD 和肠 TB 诊断患者的发病率时间趋势。
共查阅了 632 份病历记录，排除了 60 份因数据不足或不符合诊断标准的病历。572 例患者中，224 例为肠 TB（中位数年龄 37 岁，IQR 22；125 例[56%]为女性），348 例为 CD（中位数年龄 40 岁，IQR 25；159 例[46%]为女性[与 TB 相比，p<0.02]）。因此，研究期间更多患者患有 CD，但两种疾病的发病率之间没有相关性（r=0.318；p=0.25）。
在印度的一家私立医疗机构中，15 年来肠 TB 和 CD 的发病率之间没有负相关。
