Kaltseis Katharina, Frank Florian, Broessner Gregor
Neurology, Innsbruck Medical University Department of Neurology, Innsbruck, Austria.
Neurology, Innsbruck Medical University Department of Neurology, Innsbruck, Austria
BMJ Case Rep. 2021 Apr 12;14(4):e240783. doi: 10.1136/bcr-2020-240783.
Persistent migraine aura without infarction is a rare but debilitating condition. Treatment options are mostly anecdotal and limited due to inefficacy and side effects. We present a 16-year-old female patient with triple X syndrome, having persistent aura symptoms for over 2 years, consisting of continuous visual and sensory sensations. Previous treatments with seven different migraine preventatives were not successful. The patient successfully responded to zonisamide against refractory prolonged aura and remained symptom-free under the ongoing treatment without any relevant side effects. Zonisamide may be considered a new and safe treatment option for patients with persistent migraine aura.
持续性偏头痛性先兆且无梗死是一种罕见但使人衰弱的病症。由于疗效不佳和副作用，治疗选择大多只是传闻且有限。我们报告一名患有XXX综合征的16岁女性患者，其持续性先兆症状超过2年，包括持续的视觉和感觉症状。先前使用七种不同的偏头痛预防性药物治疗均未成功。该患者使用唑尼沙胺治疗难治性延长性先兆取得成功，且在持续治疗期间无症状，无任何相关副作用。唑尼沙胺可被视为持续性偏头痛性先兆患者的一种新的安全治疗选择。
