Bevilacqua M A, Costanzo F, Buonaguro L, Cimino F
Istituto di Scienze Biochimiche, II Facoltà di Medicina e Chirurgia, Università di Napoli.
Ital J Biochem. 1988 Jan-Feb;37(1):1-7.
The typical tissue isoferritin pattern varies during neoplastic transformation, usually shifting toward a more acidic profile. To investigate the molecular basis of this phenomenon, we have analyzed the steady-state levels of the H and L mRNAs in several neoplastic tissues. By using specific probes for the two ferritin subunits, we have found, in three different adenocarcinomas and in a case of Hodgkin lymphoma, a two- to four-fold increase of the H and L mRNA levels compared to those found in normal human liver.
典型的组织同工铁蛋白模式在肿瘤转化过程中会发生变化，通常会向更酸性的谱型转变。为了研究这一现象的分子基础，我们分析了几种肿瘤组织中H和L mRNA的稳态水平。通过使用针对两种铁蛋白亚基的特异性探针，我们发现在三种不同的腺癌和一例霍奇金淋巴瘤中，H和L mRNA水平相较于正常人肝脏中的水平增加了两到四倍。
