突尼斯血红蛋白[α2β2 124（H2）脯氨酸→丝氨酸]，一种通过高效液相色谱法鉴定出的新型β链变体。
Hb Tunis [alpha 2 beta 2 124 (H2)Pro----Ser], a new beta chain variant identified by HPLC.
作者信息
Mrad A, Blouquit Y, Lacombe C, Blibech R, Arous N, Bardakdjian J, Kastally R, Rosa J, Galacteros F
机构信息
Hôpital Habib Thameur, Tunis, Tunisie.
出版信息
Hemoglobin. 1988;12(1):23-30. doi: 10.3109/03630268808996879.
PMID:3384695
Abstract
During a routine hematological investigation of a child from Tunis, a silent hemoglobin variant was discovered by isoelectric-focusing. This variant was not detectable by conventional electrophoretic methods, had normal stability, expression, and oxygen affinity, and did not produce any clinical symptoms. This new variant beta 124(H2)Pro----Ser was named Hb Tunis.
摘要
在对一名来自突尼斯的儿童进行常规血液学检查时，通过等电聚焦发现了一种无症状血红蛋白变异体。这种变异体用传统电泳方法无法检测到，具有正常的稳定性、表达和氧亲和力，且未产生任何临床症状。这种新的β124(H2)脯氨酸→丝氨酸变异体被命名为Hb突尼斯。
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