血红蛋白布雷斯特[β127（H5）谷氨酰胺→赖氨酸]，一种位于α1β1界面且具有特定电泳行为的新型不稳定人类血红蛋白变体。
Hemoglobin Brest [beta 127 (H5)Gln----Lys] a new unstable human hemoglobin variant located at the alpha 1 beta 1 interface with specific electrophoretic behavior.
作者信息
Baudin-Chich V, Wajcman H, Gombaud-Saintonge G, Arous N, Riou J, Brière J, Galacteros F
机构信息
INSERM U299, Le Kremlin-Bicêtre, France.
出版信息
Hemoglobin. 1988;12(2):179-88. doi: 10.3109/03630268808998024.
Hb Brest [beta 127 (H5)Gln----Lys] is a new unstable variant located at the alpha 1 beta 1 interface at the same position as Hb Complutense [beta 127(H5)Gln----Glu]. In each of these, the substitution produces a distinct alteration in charge, yet both variants move with Hb A in conventional electrophoresis. This peculiar electrophoretical behavior may be due to the molecular position of the modified residue, which is deeply buried inside the tetramer.
血红蛋白布雷斯特[β127（H5）谷氨酰胺→赖氨酸]是一种新的不稳定变体，位于α1β1界面，与血红蛋白孔普卢滕塞[β127（H5）谷氨酰胺→谷氨酸]处于相同位置。在这两种变体中，替换都会导致电荷发生明显变化，但在传统电泳中，这两种变体都与血红蛋白A一起移动。这种特殊的电泳行为可能是由于修饰残基的分子位置，该残基深埋在四聚体内部。
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