Iida Noriyuki, Takemura Kosuke, Ito Masaya, Funata Nobuaki, Yonese Ichiro, Suzuki Hiroaki, Tsuzuki Toyonori, Koga Fumitaka
118084Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
12703Aichi Medical University Hospital, Aichi, Japan.
Int J Surg Pathol. 2021 Dec;29(8):887-891. doi: 10.1177/10668969211008980. Epub 2021 Apr 13.
A 40-year-old, male, Japanese patient presented with the complaint of painless, right testicular swelling. Tumor markers for testicular cancer were normal. He underwent radical orchiectomy with the clinical diagnosis of stage I seminoma. Pathological examination revealed seminoma and coexisting neuroendocrine tumor (NET). Germ cell neoplasia in situ (GCNIS) was present in the vicinity of seminoma, but there was no continuity between NET and seminoma. Tumor cells of both lesions displayed amplification of 12p and isochromosome 12p on fluorescence in situ hybridization, suggesting that both tumors originated from GCNIS. The present report is the first to describe a case of primary testicular NET coexisting with seminoma in an ipsilateral testis.
一名40岁的日本男性患者因右侧睾丸无痛性肿大前来就诊。睾丸癌的肿瘤标志物正常。他接受了根治性睾丸切除术，临床诊断为I期精原细胞瘤。病理检查显示为精原细胞瘤并伴有神经内分泌肿瘤（NET）。精原细胞瘤附近存在原位生殖细胞肿瘤（GCNIS），但NET与精原细胞瘤之间没有连续性。荧光原位杂交显示，两个病灶的肿瘤细胞均出现12p扩增和12号等臂染色体，提示两种肿瘤均起源于GCNIS。本报告首次描述了一例原发性睾丸NET与同侧睾丸精原细胞瘤共存的病例。
