亚甲基四氢叶酸还原酶与无精子症相关性的评估：一项荟萃分析。
Evaluation of association between methylenetetrahydrofolate reductase and azoospermia: A meta-analysis.
机构信息
Department of Andrology, Wuxi Hosptial of Traditional Chinese Medicine, Wuxi, China.
出版信息
Medicine (Baltimore). 2021 Apr 16;100(15):e24523. doi: 10.1097/MD.0000000000024523.
BACKGROUND
Infertility affects childbearing age couples all over the world. One of the important reasons for infertility is genetic factors. Our study evaluated the association between methylenetetrahydrofolate reductase (MTHFR) and azoospermia.
METHODS
Multiple databases like MEDLINE, EMBASE, Cochrane library, and China journal full-text database were used to search for relevant studies, and full-text articles involved in the evaluation of MTHFR and azoospermia. The results were evaluated using STATA 12.0. Heterogeneity analysis, sensitivity analysis, and bias analysis were also performed on the data.
RESULTS
Thirteen related studies eventually met the inclusion criteria. Significant association between C677T polymorphism and azoospermia (relative risk [RR] = 0.94 [0.90, 0.99], I2 = 60.9%, P = .002), and between A1298C polymorphism and azoospermia (RR = 0.98 [0.94, 1.02], I2 = 56.3%, P = .011) was observed. Meanwhile, in subgroup analysis, Caucasians had higher risk than Mongolians in association between MTHFR and azoospermia.
CONCLUSION
There was association between MTHFR polymorphism and azoospermia. Caucasian populations had higher risk than Mongolian populations in association between MTHFR and azoospermia.
背景
不孕症影响着全世界育龄夫妇。不孕症的一个重要原因是遗传因素。我们的研究评估了亚甲基四氢叶酸还原酶（MTHFR）与无精子症之间的关系。
方法
我们使用 MEDLINE、EMBASE、Cochrane 图书馆和中国期刊全文数据库等多个数据库，搜索评估 MTHFR 和无精子症的相关研究，并纳入全文文章。使用 STATA 12.0 评估结果。我们还对数据进行了异质性分析、敏感性分析和偏差分析。
结果
最终有 13 项相关研究符合纳入标准。C677T 多态性与无精子症之间存在显著关联（相对风险 [RR] = 0.94 [0.90, 0.99]，I2 = 60.9%，P = 0.002），A1298C 多态性与无精子症之间也存在显著关联（RR = 0.98 [0.94, 1.02]，I2 = 56.3%，P = 0.011）。同时，在亚组分析中，MTHFR 与无精子症之间的关联，白种人比蒙古人风险更高。
结论
MTHFR 多态性与无精子症之间存在关联。MTHFR 与无精子症之间的关联，白种人比蒙古人风险更高。
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