Department of Cardiology and Neurology.
Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul.
Medicine (Baltimore). 2021 Apr 16;100(15):e25503. doi: 10.1097/MD.0000000000025503.
Post-stroke constipation is a major complication of stroke and increases the incidence of poor neurological outcomes and infectious complications and, therefore, warrants active and prompt treatment. In East Asian countries, several types of herbal medicines have been used for the treatment of post-stroke constipation because they are considered safer than existing pharmacotherapies. However, no systematic review has investigated the efficacy and safety of traditional East Asian herbal medicine in the treatment of post-stroke constipation. With this systematic review and meta-analysis, we aimed to evaluate the efficacy and safety of traditional East Asian herbal medicines for the treatment of post-stroke constipation.
Eight electronic databases will be searched for relevant studies published from inception to April 2021. Only randomized controlled trials (RCTs) that assess the efficacy and safety of traditional East Asian herbal medicines for the treatment of post-stroke constipation will be included in this study. The methodological qualities, including the risk of bias, will be evaluated using the Cochrane risk of bias assessment tool. After screening the studies, a meta-analysis of the RCTs will be performed, if possible.
This study is expected to generate high-quality evidence of the efficacy and safety of herbal medicines to treat post-stroke constipation.
Our systematic review will provide evidence to determine whether herbal medicines can be effective interventions for patients with post-stroke constipation.
Ethical approval is not required, as this study was based on a review of published research. This review will be published in a peer-reviewed journal and disseminated electronically and in print.
Research registry reviewregistry1117.
中风后便秘是中风的主要并发症之一，会增加不良神经预后和感染性并发症的发生率，因此需要积极和及时的治疗。在东亚国家，已经使用了几种类型的草药来治疗中风后便秘，因为它们被认为比现有的药物治疗更安全。然而，还没有系统评价研究过传统东亚草药治疗中风后便秘的疗效和安全性。通过这项系统评价和荟萃分析，我们旨在评估传统东亚草药治疗中风后便秘的疗效和安全性。
将从建库到 2021 年 4 月检索到的相关研究纳入 8 个电子数据库。本研究仅纳入评估传统东亚草药治疗中风后便秘疗效和安全性的随机对照试验（RCT）。将使用 Cochrane 偏倚风险评估工具评估研究的方法学质量，包括偏倚风险。在筛选研究后，如果可能的话，将对 RCT 进行荟萃分析。
本研究有望生成高质量的证据，证明草药治疗中风后便秘的疗效和安全性。
我们的系统评价将为确定草药是否可以成为中风后便秘患者的有效干预措施提供证据。
由于本研究基于对已发表研究的回顾，因此不需要伦理批准。本综述将发表在同行评议的期刊上，并通过电子和印刷方式传播。
Research registry reviewregistry1117。
