• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

通过DNA聚合酶α全酶的自杀失活实现低毒性癌症化疗：新型噻唑烷基和全氢噻嗪基乙基氮芥磷酰胺酯的初步结果

Low toxicity cancer chemotherapy by suicide inactivation of DNA polymerase alpha holoenzyme: first results with new thiazolidinyl- and perhydrothiazinyl-ethyl-N-mustard-phosphamide esters.

作者信息

Hohorst H J, Bielicki L, Müller K, Voelcker G

机构信息

Gustav-Embden-Zentrum of Biological Chemistry, University of Frankfurt/Main, Federal Republic of Germany.

出版信息

J Cancer Res Clin Oncol. 1988;114(3):309-11. doi: 10.1007/BF00405840.

DOI:10.1007/BF00405840
PMID:3384844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12243753/
Abstract

Thiazolidinyl- and perhydrothiazinyl-ethyl-N-mustard-phosphamide esters were designed to act as highly specific suicide inactivators of DNA polymerase alpha holoenzymes. Acute and subacute toxicity of these drugs in mice was very small. By daily i.p. injection, on day 0-4 mice were cured of P 388 lymphatic leukaemia with no depression of blood leucocytes. The findings suggest that suicide inactivators of DNA polymerase alpha holoenzyme may be promising drugs for low toxicity cancer chemotherapy.

摘要

噻唑烷基和全氢噻嗪基乙基-N-芥子气磷酰胺酯被设计用作DNA聚合酶α全酶的高度特异性自杀性灭活剂。这些药物对小鼠的急性和亚急性毒性非常小。通过每日腹腔注射，在第0至4天，P 388淋巴细胞白血病小鼠被治愈，且血液白细胞未出现减少。这些发现表明，DNA聚合酶α全酶的自杀性灭活剂可能是低毒性癌症化疗的有前景的药物。

相似文献

1
Low toxicity cancer chemotherapy by suicide inactivation of DNA polymerase alpha holoenzyme: first results with new thiazolidinyl- and perhydrothiazinyl-ethyl-N-mustard-phosphamide esters.通过DNA聚合酶α全酶的自杀失活实现低毒性癌症化疗：新型噻唑烷基和全氢噻嗪基乙基氮芥磷酰胺酯的初步结果
J Cancer Res Clin Oncol. 1988;114(3):309-11. doi: 10.1007/BF00405840.
2
Thiazolidinyl- and perhydrothiazinylphosphamidesters: toxicity and preliminary antitumour evaluation.噻唑烷基和全氢噻嗪基磷酰胺酯：毒性及初步抗肿瘤评估
J Cancer Res Clin Oncol. 1997;123(11-12):623-31. doi: 10.1007/s004320050116.
3
Systemic treatments for metastatic cutaneous melanoma.转移性皮肤黑色素瘤的全身治疗
Cochrane Database Syst Rev. 2018 Feb 6;2(2):CD011123. doi: 10.1002/14651858.CD011123.pub2.
4
In vitro and in vivo anticancer activity of mitozolomide and sparsomycin in human tumor xenografts, murine tumors and human bone marrow.米托唑胺和稀疏霉素在人肿瘤异种移植、小鼠肿瘤及人骨髓中的体内外抗癌活性
J Cancer Res Clin Oncol. 1990;116(6):550-6. doi: 10.1007/BF01637073.
5
Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents.用于儿童和青少年慢性非癌性疼痛的非甾体抗炎药（NSAIDs）
Cochrane Database Syst Rev. 2017 Aug 2;8(8):CD012537. doi: 10.1002/14651858.CD012537.pub2.
6
Anti-tumour effect of alpha-amino N-substituted-pyrrolidin-2,5-dione-N-mustards on the growth of P388 lymphocytic leukaemia.α-氨基-N-取代-吡咯烷-2,5-二酮-N-氮芥对P388淋巴细胞白血病生长的抗肿瘤作用。
J Cancer Res Clin Oncol. 1987;113(2):151-4. doi: 10.1007/BF00391437.
7
Bendamustine for patients with indolent B cell lymphoid malignancies including chronic lymphocytic leukaemia.苯达莫司汀用于治疗惰性B细胞淋巴瘤患者，包括慢性淋巴细胞白血病。
Cochrane Database Syst Rev. 2012 Sep 12;2012(9):CD009045. doi: 10.1002/14651858.CD009045.pub2.
8
Interventions for fertility preservation in women with cancer undergoing chemotherapy.对接受化疗的癌症女性进行生育力保存的干预措施。
Cochrane Database Syst Rev. 2025 Jun 19;6:CD012891. doi: 10.1002/14651858.CD012891.pub2.
9
A rapid and systematic review of the clinical effectiveness and cost-effectiveness of paclitaxel, docetaxel, gemcitabine and vinorelbine in non-small-cell lung cancer.对紫杉醇、多西他赛、吉西他滨和长春瑞滨在非小细胞肺癌中的临床疗效和成本效益进行的快速系统评价。
Health Technol Assess. 2001;5(32):1-195. doi: 10.3310/hta5320.
10
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.慢性斑块状银屑病的全身药理学治疗：一项网状荟萃分析。
Cochrane Database Syst Rev. 2017 Dec 22;12(12):CD011535. doi: 10.1002/14651858.CD011535.pub2.

引用本文的文献

1
Enhancement of antitumor activity of the oxazaphosphorine cytostatic SUM-IAP by N-methylformamide.N-甲基甲酰胺增强恶唑磷氮芥类细胞抑制剂SUM-IAP的抗肿瘤活性。
J Cancer Res Clin Oncol. 2016 Jun;142(6):1183-9. doi: 10.1007/s00432-016-2132-5. Epub 2016 Mar 3.

本文引用的文献

1
Activated cyclophosphamide: an enzyme-mechanism-based suicide inactivator of DNA polymerase/3'-5' exonuclease.活化环磷酰胺：一种基于酶机制的DNA聚合酶/3'-5'核酸外切酶自杀性灭活剂。
J Cancer Res Clin Oncol. 1984;107(3):195-8. doi: 10.1007/BF01032606.
2
Mammalian DNA polymerase alpha holoenzymes with possible functions at the leading and lagging strand of the replication fork.哺乳动物DNA聚合酶α全酶在复制叉的前导链和后随链可能具有的功能。
Proc Natl Acad Sci U S A. 1984 Jul;81(13):3993-7. doi: 10.1073/pnas.81.13.3993.
3
Enzymatic toxicogenation of "activated" cyclophosphamide by 3'-5' exonucleases.3'-5'核酸外切酶对“活化”环磷酰胺的酶促毒化作用。
J Cancer Res Clin Oncol. 1983;105(1):27-9. doi: 10.1007/BF00391828.
4
Enzymatic synthesis of deoxyribonucleic acid. 36. A proofreading function for the 3' leads to 5' exonuclease activity in deoxyribonucleic acid polymerases.脱氧核糖核酸的酶促合成。36. 脱氧核糖核酸聚合酶中3'至5'核酸外切酶活性的校对功能。
J Biol Chem. 1972 Jan 10;247(1):241-8.
5
The enzymatic basis of cyclophosphamide specificity.环磷酰胺特异性的酶学基础。
Adv Enzyme Regul. 1986;25:99-122. doi: 10.1016/0065-2571(86)90010-5.
6
A new mammalian DNA polymerase with 3' to 5' exonuclease activity: DNA polymerase delta.一种具有3'至5'核酸外切酶活性的新型哺乳动物DNA聚合酶：DNA聚合酶δ
Biochemistry. 1976 Jun 29;15(13):2817-23. doi: 10.1021/bi00658a018.
7
[Intravenous injections in mice by the retrobulbar plexus route].[通过球后丛神经途径对小鼠进行静脉注射]
Z Versuchstierkd. 1979;21(3):177-81.