TRPA1 通道：“神经血管耦联”领域的新成员。
TRPA1 channel: New kid in the 'neurovascular coupling' town.
机构信息
Department of Pharmacology, University of Vermont, Burlington, VT, USA.
Department of Pharmacology, University of Vermont, Burlington, VT, USA; Division of Cardiovascular Sciences, University of Manchester, Manchester, UK.
出版信息
Cell Calcium. 2021 Jun;96:102407. doi: 10.1016/j.ceca.2021.102407. Epub 2021 Apr 6.
The just-in time delivery of oxygen and nutrients to active brain regions to support function (functional hyperemia; FH) is mediated by not yet fully understood mechanisms collectively referred to as 'neurovascular coupling' (NVC). In a recent publication (eLife 2021) Thakore et al. provide profound mechanistic insight how the capillary endothelial transient receptor potential ankyrin 1 (TRPA1) channel contribute to blood flow control and functional hyperemia in the brain.
氧和营养物质被及时递送至活跃的脑区以支持功能（功能性充血；FH），这一过程由尚未完全阐明的机制介导，这些机制被统称为“神经血管耦联”（NVC）。在最近的一篇论文（eLife 2021）中，Thakore 等人提供了深刻的机制见解，说明毛细血管内皮瞬态受体电位锚蛋白 1（TRPA1）通道如何有助于大脑中的血流控制和功能性充血。
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