IVI RMA Madrid, Av del Talgo 68, Madrid 28035, Spain.
IVI RMA Madrid, Av del Talgo 68, Madrid 28035, Spain; Rey Juan Carlos University, Madrid, Spain.
Reprod Biomed Online. 2021 Jun;42(6):1211-1218. doi: 10.1016/j.rbmo.2021.03.006. Epub 2021 Mar 15.
Anti-Müllerian hormone (AMH) is the most established biomarker for estimating ovarian reserve. No reliable marker of oocyte quality, however, is available. Is there an association between the rates of aneuploidy and the different ranges of serum AMH levels?
Retrospective, single-centre study of 1718 patients undergoing intracytoplasmic sperm injection and preimplantation genetic testing with aneuploidy at the blastocyst stage between January 2015 and December 2019. Patients were stratified into six different categories of AMH (ng/ml) according to percentile distribution.
Although a higher number of biopsied embryos were found for higher AMH levels (P = 0.017), a lower rate of biopsied blastocysts per metaphase II (P = 0.019) and per fertilized oocyte (0.023) was observed in this group of high AMH. A higher number of euploid embryos was found for higher AMH values (P = 0.031); however, the rate of aneuploid embryos per metaphase II or per fertilized oocyte was not significantly different across the six groups. No differences were observed in the implantation, pregnancy and ongoing pregnancy rate, or in the miscarriage and biochemical loss rate. Regression analysis did not show any significant correlation between AMH and aneuploid embryos.
In this large series of patients, AMH was not related to embryo aneuploidy.
抗苗勒管激素（AMH）是评估卵巢储备功能最常用的生物标志物。然而，目前尚无可靠的卵母细胞质量标志物。非整倍体率与血清 AMH 水平的不同范围之间是否存在关联？
这是一项回顾性、单中心研究，纳入了 2015 年 1 月至 2019 年 12 月期间在体外受精和胚胎植入前遗传学检测中处于囊胚阶段的 1718 例患者。根据百分位分布，患者被分为六组不同的 AMH（ng/ml）水平。
虽然 AMH 水平较高的患者活检胚胎数量较多（P=0.017），但这组高 AMH 患者的活检囊胚数/每枚中期 II 卵母细胞（P=0.019）和活检囊胚数/每枚受精卵母细胞（P=0.023）较低。较高的 AMH 值与更多的整倍体胚胎相关（P=0.031）；然而，六组之间每枚中期 II 卵母细胞或每枚受精卵母细胞的非整倍体胚胎率并无显著差异。胚胎着床率、妊娠率、持续妊娠率，流产率和生化丢失率均无差异。回归分析显示 AMH 与非整倍体胚胎之间无显著相关性。
在这项大型患者系列研究中，AMH 与胚胎非整倍体无关。
