Department of Endocrinology, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China; Department of Endocrinology, Second Hospital of Shijiazhuang, 53 Huaxi Road, Shijiazhuang, Hebei, 050000, China.
Department of Endocrinology, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.
Prim Care Diabetes. 2021 Aug;15(4):682-687. doi: 10.1016/j.pcd.2021.03.003. Epub 2021 Apr 10.
This study aimed to determine the association between serum uric acid (UA) levels and cardiovascular events in hospitalized patients with type 2 diabetes mellitus (T2DM).
A retrospective cohort study was conducted in 2227 hospitalized patients with T2DM. Cox proportional hazards regression was used to assess the association between serum UA and cardiovascular events, including cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, heart failure, unstable angina, and arrhythmias requiring hospitalization.
Among 1314 men, 143 (10.9%) experienced cardiovascular events. Serum UA level was not associated with the risk of cardiovascular events (hazard ratio [HR] per 100 μmol/L increase in serum UA: 1.12, 95% confidence interval [CI]: 0.90-1.40). Among 913 women, 96 (10.5%) experienced cardiovascular events. For every 100 μmol/L increase in serum UA level, the risk of experiencing a cardiovascular event increased by 27% (HR: 1.27, 95% CI: 1.02-1.57).
In hospitalized patients with T2DM, baseline serum UA levels were positively associated with cardiovascular events in women, but not in men. Serum UA levels may be a significant independent risk factor for cardiovascular events in women with T2DM.
本研究旨在探讨血清尿酸（UA）水平与住院 2 型糖尿病（T2DM）患者心血管事件的相关性。
本研究采用回顾性队列研究，纳入 2227 例住院 T2DM 患者。采用 Cox 比例风险回归分析评估血清 UA 与心血管事件（包括心血管死亡、非致死性心肌梗死、非致死性卒中等）的相关性。
在 1314 名男性患者中，有 143 例（10.9%）发生心血管事件。血清 UA 水平与心血管事件风险无显著相关性（每增加 100μmol/L 血清 UA，风险比[HR]：1.12，95%置信区间[CI]：0.90-1.40）。在 913 名女性患者中，有 96 例（10.5%）发生心血管事件。与每增加 100μmol/L 血清 UA 水平相比，女性患者发生心血管事件的风险增加了 27%（HR：1.27，95%CI：1.02-1.57）。
在住院 T2DM 患者中，基线血清 UA 水平与女性患者的心血管事件呈正相关，而与男性患者无相关性。血清 UA 水平可能是女性 T2DM 患者发生心血管事件的一个重要独立危险因素。
