Collins R A, Parsons K R, Field T R, Bramley A J
AFRC Institute for Animal Disease Research, Compton Laboratory, Newbury, UK.
J Dairy Res. 1988 Feb;55(1):25-32. doi: 10.1017/s0022029900025814.
Xanthine oxidase (XO) was demonstrated to be present in the teat canal and secretory tissue of the bovine mammary gland by histochemical techniques. Homogenates of these tissues were able to replace XO in an antibacterial assay with Streptococcus uberis. The action of XO on its substrate hypoxanthine was shown to provide an essential component for anti-streptococcal activity mediated by lactoperoxidase. A mechanism is proposed whereby the interaction of XO, lactoperoxidase and thiocyanate may provide antibacterial activity in the teat canal.
通过组织化学技术证明，黄嘌呤氧化酶（XO）存在于牛乳腺的乳头管和分泌组织中。这些组织的匀浆在与乳房链球菌的抗菌试验中能够替代XO。XO对其底物次黄嘌呤的作用被证明是乳铁蛋白介导的抗链球菌活性的重要组成部分。本文提出了一种机制，即XO、乳铁蛋白和硫氰酸盐的相互作用可能在乳头管中提供抗菌活性。
