Muraoka Hirotaka, Ito Kotaro, Hirahara Naohisa, Okada Shunya, Kondo Takumi, Kaneda Takashi
Department of Radiology, Nihon University School of Dentistry At Matsudo, 2-870-1 Sakaecho-Nishi, Matsudo, Chiba, 271-8587, Japan.
Oral Radiol. 2022 Jan;38(1):57-62. doi: 10.1007/s11282-021-00526-6. Epub 2021 Apr 13.
The purpose of this study was to investigate the age-related changes in apparent diffusion coefficient (ADC) values of the mandibular bone marrow using diffusion-weighted imaging (DWI).
This retrospective cohort study comprised all patients who underwent pantomography and magnetic resonance imaging (MRI) between April 2018 and November 2020 at our institution. A total of 351 participants (140 men, 211 women), aged 15-89 years (mean age 46.01 years), were included in the study. Spearman's correlation coefficients were calculated using age groups as the criterion variable and the ADC values as the explanatory variables. P < 0.05 was considered statistically significant.
The mean ADC value for all age groups was 0.91 ± 0.18 in men and 0.86 ± 0.16 in women (p = 0.016). There was a significant negative correlation between age and the ADC values in each sex group (p < 0.001).
This study demonstrates that the normal ADC values of the mandibular bone marrow show significant negative correlation with increasing age. These findings will be useful in the diagnosis of bone marrow diseases.
本研究旨在利用扩散加权成像（DWI）研究下颌骨骨髓表观扩散系数（ADC）值随年龄的变化。
这项回顾性队列研究纳入了2018年4月至2020年11月期间在本机构接受全景X线体层摄影术和磁共振成像（MRI）检查的所有患者。共有351名参与者（140名男性，211名女性），年龄在15 - 89岁（平均年龄46.01岁）被纳入研究。以年龄组作为标准变量，ADC值作为解释变量计算Spearman相关系数。P < 0.05被认为具有统计学意义。
所有年龄组男性的平均ADC值为0.91±0.18，女性为0.86±0.16（p = 0.016）。每个性别组的年龄与ADC值之间存在显著负相关（p < 0.001）。
本研究表明，下颌骨骨髓的正常ADC值与年龄增长呈显著负相关。这些发现将有助于骨髓疾病的诊断。
