铜催化的对甲苯磺酰腙和 2-吡啶酮的区域选择性偶联：一种合成 N-烷基化化合物的策略。

Copper-Catalyzed Regioselective Coupling of Tosylhydrazones and 2-Pyridones: A Strategy for the Production of N-Alkylated Compounds.

机构信息

Nanjing Chia Tai-Tianqing Pharmaceutical Co., Ltd., Hengguang Road No. 99-1, Qixia Nanjing, Jiangsu 210046, People's Rupublic of China.

Pharmaron (Shang Hai), Jinke Road No. 2727, Shang Hai 201203, People's Rupublic of China.

出版信息

J Org Chem. 2021 May 7;86(9):6918-6926. doi: 10.1021/acs.joc.1c00009. Epub 2021 Apr 14.

DOI:10.1021/acs.joc.1c00009

PMID:33852298

Abstract

The highly regioselective N-alkylation reaction of 2-pyridones was achieved through hydrazone chemistry, especially for substrates with bulky secondary alkyl groups. Described herein is a copper-catalyzed coupling reaction of pyridone derivatives with tosylhydrazones.

摘要

通过腙化学实现了 2-吡啶酮的高区域选择性 N-烷基化反应，特别是对于具有大体积仲烷基基团的底物。本文描述了一种铜催化的吡啶酮衍生物与对甲苯磺酰腙的偶联反应。