From the Department of Neurology (Dr Yang); Department of Medical Research (Dr Yang, Ms Lu, Dr Yan), Kuang Tien General Hospital, Taichung, Taiwan; Institute of Biomedical Nutrition, Hung Kuang University, Taichung, Taiwan (Dr Yang, Dr Yan); Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan (Dr Li); Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan (Dr Li); Department of Safety, Health, and Environmental Engineering, Hung Kuang University, Taichung, Taiwan (Dr Huang); Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan (Dr Yu); Department of Healthcare Administration, Asia University, Taichung, Taiwan (Dr Yang); Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan (Dr Lang); National Yang Ming Chiao Tung University, Taipei, Taiwan (Dr Lang); Department of Endocrinology and Metabolism, Kuang Tien General Hospital, Taichung, Taiwan (Dr Yan).
J Occup Environ Med. 2021 Sep 1;63(9):742-751. doi: 10.1097/JOM.0000000000002222.
To investigate the association between the risk of stroke and exposure to particulate matter with an aerodynamic diameter less than 2.5 μm (PM2.5) over various exposure periods.
This was a nationwide population-based case-control study in which 10,035 incident patients with a primary diagnosis of ischemic stroke each were matched with two randomly selected controls for sex, age, Charlson Comorbidity Index, year of stroke diagnosis, and level of urbanization. Multiple logistic models adjusted for potential confounders were used to assess the association of PM2.5 with ischemic stroke incidence.
There were significant short-term, medium-term, and long-term relationships between PM2.5 exposure and ischemic stroke incidence.
This study supports existing evidence that PM2.5 should be considered a risk factor for ischemic stroke.
探讨不同暴露时间段内，细颗粒物（PM2.5）暴露与卒中风险之间的关联。
这是一项全国范围内基于人群的病例对照研究，共纳入 10035 例首发缺血性卒中患者作为病例，每名患者匹配 2 名性别、年龄、Charlson 合并症指数、卒中诊断年份和城市化水平相匹配的随机对照者。采用多因素 logistic 模型调整潜在混杂因素后，评估 PM2.5 与缺血性卒中发病之间的关联。
PM2.5 暴露与缺血性卒中发病之间存在显著的短期、中期和长期关联。
本研究支持现有证据，即 PM2.5 应被视为缺血性卒中的一个危险因素。
