Bergqvist D, Jensen N, Persson N H
Department of Surgery, General Hospital, Malmö, Sweden.
Int Angiol. 1988 Jan-Mar;7(1):65-70.
A study was undertaken to evaluate the effect of a covalent heparinization on thrombogenicity of ePTFE grafts in sheep. With scanning electron microscopy heparinization occurred as a thin smooth layer covering the network of ePTFE. Most of it had disappeared already after 2 hours. In long-term experiments a high and low flow part of the ePTFE graft was created in the carotid artery system. The heparinization had no effect on patency and there was no difference between the high and low flow parts of the graft. The graft surface was covered with fibrous tissue, which was significantly thicker than the pannus in the host vessel. In the graft interstices (internodal distance of 30 micron) capillaries were seen without difference between occluded and patent grafts. The capillary density was significantly higher proximally than distally.
开展了一项研究以评估共价肝素化对绵羊体内ePTFE移植物血栓形成性的影响。通过扫描电子显微镜观察，肝素化表现为覆盖在ePTFE网络上的一层薄而光滑的层。大部分在2小时后就已消失。在长期实验中，在颈动脉系统中创建了ePTFE移植物的高流量和低流量部分。肝素化对通畅性没有影响，移植物的高流量和低流量部分之间也没有差异。移植物表面覆盖有纤维组织，其明显比宿主血管中的血管翳厚。在移植物间隙（节间距离为30微米）中可见毛细血管，闭塞和通畅的移植物之间没有差异。近端的毛细血管密度明显高于远端。
