Universidade Federal do Maranhão, Programa de Pós-Graduação em Biodiversidade e Biotecnologia da Amazônia Legal (Rede Bionorte), São Luís, Maranhão, Brazil.
Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Programa de Pós-Graduação em Saúde da Criança e do Adolescente, Ribeirão Preto, São Paulo, Brazil.
Rev Inst Med Trop Sao Paulo. 2021 Apr 12;63:e26. doi: 10.1590/S1678-9946202163026. eCollection 2021.
Sepsis is the organ dysfunction resulting from an infection associated with an unregulated host inflammatory response, which generates high mortality rates in Brazil. The aim of this stydy was to analyze the trend of early, late and post-neonatal mortality rates due to sepsis in Brazilian regions, from 2009 to 2018. This is an ecological study of time series. The trend of infant mortality from sepsis was analyzed using the International Classification of Diseases (ICD10) according to the place of residence (North, Northeast, Southeast, South and Midwest). Death Certificate data were collected from the Mortality Information System database. The temporal trend was analyzed using the Prais-Winsten estimate, interpreted as increasing, decreasing or stable, through the dependent variable (logarithm of mortality rates) and interdependent variables (years of the historical series). The Stata 14.0 statistical software was used. There were 39,867 infant deaths due to sepsis (78.67% for unspecified bacterial sepsis of the neonate ). Most of the children were male, had mixed ethnicity (black and white) , were born preterm with low birth weight and most mothers were 20-34 years old. There were decreasing trends in mortality rates from 2009 to 2018: early neonatal, in the Southeast (-3.57%), North (-3.33%) and South (-2.91%); late neonatal, in the South (-4.12%), Southeast (-4.53%), North (-4.55%) and Midwest (-6.21%); and post-neonatal, in the Northeast (-1.84%), North (-3.62%), Southeast (-3.83%) and Midwest (-5.81%). The Northeast showed a stable trend in early and late neonatal mortality rates. It was concluded that most regions showed a decreasing trend in mortality rates from sepsis in all age components, despite regional differences.
败血症是由感染引起的器官功能障碍，与不受调节的宿主炎症反应有关，在巴西导致高死亡率。本研究旨在分析 2009 年至 2018 年巴西各地区因败血症导致的早期、晚期和新生儿后死亡率趋势。这是一项时间序列的生态学研究。根据居住地（北部、东北部、东南部、南部和中西部），使用国际疾病分类（ICD10）分析婴儿因败血症死亡的趋势。从死亡率信息系统数据库中收集死亡证明数据。通过依赖变量（死亡率的对数）和相依变量（历史序列的年份），使用普赖斯-温斯坦估计分析时间趋势，解释为增加、减少或稳定。使用 Stata 14.0 统计软件。有 39867 例婴儿因败血症死亡（78.67%为新生儿未特指细菌败血症）。大多数儿童为男性，具有混合种族（黑人和白人），早产，出生体重低，大多数母亲年龄在 20-34 岁之间。2009 年至 2018 年死亡率呈下降趋势：早期新生儿，在东南部（-3.57%）、北部（-3.33%）和南部（-2.91%）；晚期新生儿，在南部（-4.12%）、东南部（-4.53%）、北部（-4.55%）和中西部（-6.21%）；新生儿后，在东北部（-1.84%）、北部（-3.62%）、东南部（-3.83%）和中西部（-5.81%）。东北部地区早期和晚期新生儿死亡率呈稳定趋势。结论是，尽管存在地区差异，但大多数地区所有年龄段的败血症死亡率均呈下降趋势。
