Kitamura S, Hirato K, Kawamura E, Yanaihara T, Nakayama T
Department of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo.
Nihon Sanka Fujinka Gakkai Zasshi. 1988 May;40(5):541-8.
To study the steroid concentration in human amniotic fluid in early stages of pregnancy between 6-10 weeks, progesterone (P4), 17 alpha-OH-progesterone (17P4), estrone (E1), estradiol (E2) and estriol (E3) levels in amniotic fluid (AF), maternal vein (MV) and chorionic tissue (CH) were measured by RIA. The levels of P4, 17P4, E1, E2 and E3 in CH were significantly higher than in AF and MV. The levels of P4 and E1 in AF were significantly higher than in MV, but the levels of 17P4 in MV were higher than in AF between 6-10 weeks of gestation. Although a peak at 7th week of gestation in AF was noticed, the levels of P4 increased gradually between 6-10 weeks of gestation in AF,MV and CH. There was no significant change in 17P4 levels in AF and CH, except for a slight decrease between 6-8 weeks of gestation in MV. The levels of E2 in MV increased after the 9th week of gestation and the levels were significantly higher than in AF. All estrogens (Es) in CH significantly increased at 10th week of gestation. The levels of P4 in AF and that in CH correlated well. A significant correlation was observed between the levels of E1 and E3 in MV and in CH. These results indicate the possible transference of P4 from CH to AF rather than that to MV. The transference of Es from CH to AF seems to be less than that of P4.(ABSTRACT TRUNCATED AT 250 WORDS)
为研究妊娠6至10周早期人羊水的类固醇浓度，采用放射免疫分析法测定羊水（AF）、母血（MV）和绒毛组织（CH）中孕酮（P4）、17α-羟孕酮（17P4）、雌酮（E1）、雌二醇（E2）和雌三醇（E3）的水平。CH中P4、17P4、E1、E2和E3的水平显著高于AF和MV。AF中P4和E1的水平显著高于MV，但在妊娠6至10周期间，MV中17P4的水平高于AF。虽然在AF中观察到妊娠第7周有一个峰值，但在妊娠6至10周期间，AF、MV和CH中P4的水平逐渐升高。AF和CH中17P4水平无显著变化，MV在妊娠6至8周之间略有下降除外。MV中E2的水平在妊娠第9周后升高，且显著高于AF。CH中所有雌激素（Es）在妊娠第10周时显著增加。AF中的P4水平与CH中的P4水平相关性良好。MV和CH中E1和E3的水平之间观察到显著相关性。这些结果表明P4可能从CH转移到AF而非MV。Es从CH转移到AF的量似乎比P4少。（摘要截断于250字）
