免疫代谢组学的 CyTOF 方法。
Immunometabolism the CyTOF way.
机构信息
Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, 310024 Hangzhou, China; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, 310024 Hangzhou, China; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, 310024 Hangzhou, China.
Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, 310024 Hangzhou, China; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, 310024 Hangzhou, China; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, 310024 Hangzhou, China.
出版信息
Immunity. 2021 Apr 13;54(4):610-613. doi: 10.1016/j.immuni.2021.03.019.
In this issue of Immunity, Levine et al. report a CyTOF-based approach for the analyses of CD8 T cells metabolic changes at the single-cell level. This approach identified a transition state early in T cell activation that is characterized by high glycolytic and oxidative activity, providing new insight into the metabolic changes that underlie the transition to effector and memory T cell fates.
在本期《免疫》中，Levine 等人报道了一种基于 CyTOF 的方法，用于分析 CD8 T 细胞在单细胞水平上的代谢变化。该方法鉴定了 T 细胞激活早期的一个过渡状态，其特征是高糖酵解和氧化活性，为理解向效应器和记忆 T 细胞命运转变的代谢变化提供了新的见解。
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